{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strizzi L"],"funding":["NCI NIH HHS"],"pagination":["1915-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3334352"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(8)"],"pubmed_abstract":["Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target."],"journal":["Cancer research"],"pubmed_title":["Nodal expression and detection in cancer: experience and challenges."],"pmcid":["PMC3334352"],"funding_grant_id":["R01CA121205","U54 CA143869","R01 CA121205-05","U54CA143869","R01 CA121205"],"pubmed_authors":["Hendrix MJ","Kirschmann DA","Strizzi L","Hardy KM","Ahrlund-Richter L"],"additional_accession":[]},"is_claimable":false,"name":"Nodal expression and detection in cancer: experience and challenges.","description":"Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Apr","modification":"2025-04-22T19:39:54.031Z","creation":"2019-03-27T00:52:35Z"},"accession":"S-EPMC3334352","cross_references":{"pubmed":["22508696"],"doi":["10.1158/0008-5472.can-11-3419","10.1158/0008-5472.CAN-11-3419"]}}