biostudies-literatureUnknown1(2)Belghiti JObjectives Postpartum haemorrhage (PPH) is a major cause of maternal mortality and morbidity worldwide. Experimental studies support the hypothesis that oxytocin administration during labour, a common although not evidence-based practice, may increase the risk of atonic PPH. The clinical studies, however, are inconclusive. The objectives of this study was to investigate the association between the level of oxytocin exposure during labour and the risk of severe PPH and to explore whether the prophylactic use of oxytocin after birth modifies this association. Design Population-based, cohort-nested case-control study. Setting 106 French hospitals from December 2004 through November 2006. Participants Women with term singleton vaginal deliveries, after an uncomplicated pregnancy. Cases wereBMJ opene000514https://www.ebi.ac.uk/biostudies/studies/S-EPMC3334825biostudies-literatureOxytocin during labour and risk of severe postpartum haemorrhage: a population-based, cohort-nested case-control study.PMC3334825Kayem GBouvier-Colle MHBelghiti JDeneux-Tharaux CDupont CRudigoz RCfalseOxytocin during labour and risk of severe postpartum haemorrhage: a population-based, cohort-nested case-control study.Objectives Postpartum haemorrhage (PPH) is a major cause of maternal mortality and morbidity worldwide. Experimental studies support the hypothesis that oxytocin administration during labour, a common although not evidence-based practice, may increase the risk of atonic PPH. The clinical studies, however, are inconclusive. The objectives of this study was to investigate the association between the level of oxytocin exposure during labour and the risk of severe PPH and to explore whether the prophylactic use of oxytocin after birth modifies this association. Design Population-based, cohort-nested case-control study. Setting 106 French hospitals from December 2004 through November 2006. Participants Women with term singleton vaginal deliveries, after an uncomplicated pregnancy. Cases were2011-01-01T00:00:00Z20112025-04-04T14:31:58.828Z2019-03-27T00:52:37ZS-EPMC33348252218935310.1136/bmjopen-2011-000514