{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kochunov P"],"funding":["NIBIB NIH HHS","NIDA NIH HHS","NCRR NIH HHS","NIMH NIH HHS","NHLBI NIH HHS"],"pagination":["65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3340599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3"],"pubmed_abstract":["<h4>Background and purpose</h4>We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity.<h4>Methods</h4>The subject pool consisted of 369 (219F; aged 28-85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter thickness, fractional anisotropy of cerebral white matter, and the volume of hyperintensive WM lesions.<h4>Results</h4>From the 13 gene expressions, significant phenotypic correlations were only found for the P- and L-selectin expression levels. Increases in P-selectin expression levels tracked with decline in cerebral integrity while the opposite trend was observed for L-selectin expression. The correlations for the P-selectin expression were driven by shared genetic factors, while the correlations with L-selectin expression were due to shared environmental effects.<h4>Conclusion</h4>This study demonstrated that P-selectin expression shared a significant variance with measurements of cerebral integrity and posits elevated P-selectin expression levels as a potential risk factor of hypertension-related cerebral atrophy."],"journal":["Frontiers in genetics"],"pubmed_title":["P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans."],"pmcid":["PMC3340599"],"funding_grant_id":["R01 MH078111","R01 MH083824","K01 EB006395","S10 RR029392","R37 MH059490","P01 HL045522","R01 DA027680"],"pubmed_authors":["Cole SA","Johnson MP","Holcomb HH","Moses EK","Kochunov V","Blangero J","Goring H","Dyer TD","Almasy L","Kochunov P","Lancaster J","Winkler AM","Hong LE","Curran JE","Olvera RL","Mitchell B","Glahn DC","Duggirala R","Kent JW"],"additional_accession":[]},"is_claimable":false,"name":"P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.","description":"<h4>Background and purpose</h4>We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity.<h4>Methods</h4>The subject pool consisted of 369 (219F; aged 28-85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter thickness, fractional anisotropy of cerebral white matter, and the volume of hyperintensive WM lesions.<h4>Results</h4>From the 13 gene expressions, significant phenotypic correlations were only found for the P- and L-selectin expression levels. Increases in P-selectin expression levels tracked with decline in cerebral integrity while the opposite trend was observed for L-selectin expression. The correlations for the P-selectin expression were driven by shared genetic factors, while the correlations with L-selectin expression were due to shared environmental effects.<h4>Conclusion</h4>This study demonstrated that P-selectin expression shared a significant variance with measurements of cerebral integrity and posits elevated P-selectin expression levels as a potential risk factor of hypertension-related cerebral atrophy.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-05-29T20:05:20.139Z","creation":"2019-06-05T17:16:02Z"},"accession":"S-EPMC3340599","cross_references":{"pubmed":["22558002"],"doi":["10.3389/fgene.2012.00065"]}}