biostudies-literatureKochunov PNIBIB NIH HHSNIDA NIH HHSNCRR NIH HHSNIMH NIH HHSNHLBI NIH HHS65https://www.ebi.ac.uk/biostudies/studies/S-EPMC3340599biostudies-literatureUnknown3<h4>Background and purpose</h4>We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity.<h4>Methods</h4>The subject pool consisted of 369 (219F; aged 28-85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three Frontiers in geneticsP-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.PMC3340599R01 MH078111R01 MH083824K01 EB006395S10 RR029392R37 MH059490P01 HL045522R01 DA027680Cole SAJohnson MPHolcomb HHMoses EKKochunov VBlangero JGoring HDyer TDAlmasy LKochunov PLancaster JWinkler AMHong LECurran JEOlvera RLMitchell BGlahn DCDuggirala RKent JWfalseP-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.<h4>Background and purpose</h4>We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity.<h4>Methods</h4>The subject pool consisted of 369 (219F; aged 28-85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three 2012-01-01T00:00:00Z20122025-05-29T20:05:20.139Z2019-06-05T17:16:02ZS-EPMC33405992255800210.3389/fgene.2012.00065