{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["International Consortium for Blood Pressure Genome-Wide Association Studies"],"funding":["NICHD NIH HHS","NIDCR NIH HHS","NIA NIH HHS","Howard Hughes Medical Institute","NIEHS NIH HHS","AHRQ HHS","NHLBI NIH HHS","NIMH NIH HHS","European Commission FP7","National Institute for Health Research (NIHR)","NINDS NIH HHS","Biotechnology and Biological Sciences Research Council","Intramural NIH HHS","Austrian Science Fund FWF","British Heart Foundation","NCRR NIH HHS","FIC NIH HHS","CIHR","Kidney Research UK","NIDDK NIH HHS","Medical Research Council","NIMHD NIH HHS","NHGRI NIH HHS","Chief Scientist Office","NCI NIH HHS","Wellcome Trust","NIGMS NIH HHS"],"pagination":["103-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3340926"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["478(7367)"],"pubmed_abstract":["Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention."],"journal":["Nature"],"pubmed_title":["Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk."],"pmcid":["PMC3340926"],"funding_grant_id":["G0501942","U01 NS069208","U01 HL084756","R01HL056931","079895","HS06516","G9521010","G9521010D","U01HG004399","R01 NS39987","PG/02/128","R01 AG017644-09S1","G0600331","G0801056B","R01 HL086694-04A1","RG/08/013/25942","U01 HL072515-06","SP/04/002","G19/35","MC_PC_U127561128","N01-HC-75150","CZB/4/710","U01 HL054466-11","CZB/4/276","N01-HC-85079","U01 HL080295","RR-024156","N01-HC-85080","U01HG004735","N01-HC-85085","5R01HL086694-03","N01-HC-85086","G0902037","N01-HC-85083","N01-HC-85084","N01AG62101","N01-HC-85081","R01HL086694","U01HG004738","N01AG62103","R01 HL087652","N01-HC-85082","R01HL06094","MC_U106179471","HL086718","N01-HC-45133","U10HL054512","5R01HL087679-02","U01HG004728","U01HG004729","U01DE018903","R01 DK078150","U01HG004726","N01AG6210","U01 HL054466","PG97012","HG005581","R01HL071051","HL080025","HL36310","FP7_201550","R01 HL085251","G0100222","R01HL087641","R01DK066574","R01HL061019","DK075787","R01 NS42733","U01 NS069208-01","HG003054","077016/Z/05/Z","NF-SI-0507-10315","G0701863","R01HL59367","N01-HC-95165","N01-HC-95166","N01-HC-95167","HL 54512","N01-HC-95168","U01 HL054471","U01 HL054473","R01 HL086694","55005617","P01CA055075","G20234","HL084729","N01-HD-1-3107","N01-HC-35129","080747/Z/06/Z","N01 HC-15103","HL54512","RG/07/005/23633","G0801056","UL1RR025005","HL085144","G8802774","U01DE01899","5R01MH63706:02","R03 TW007165","S06GM008016-380111","R01HL089650-02","U01 GM074518-04","R01HL071252","R01HL060919","R01HL071250","R01HL071251","MC_U106188470","FS05/125","M01 RR16500","U01HG004438","263 MD 9164","U01HG004436","DK062370","MOP172605","AG13196","5U01CA086308","K12RR023250","MC_U137686857","068545/Z/02","MC_U123092723","R01 AG18728","DK072193","MC_U123092720","2M01RR010284","RG/98002","N01 HC-55222","U01HG004423","R01HL071258","R01HL071259","U01HG004422","R01 CA094143","HL45508","P30ES007033","1RL1MH083268-01","CH/03/001","RG/08/008/25291","HL043851","N01-HC-95161","N01-HC-95162","N01-HC-95163","N01-HC-95164","N01-HC-95160","HHSN268200782096C","N02-HL-6-4278","263 MD 821336","PG97027","HL53353","G0902313","R01 HL073410","HL087647","RG/08/014/24067","S06GM008016-320107","DK078150","R01DK058845","G0600705","G0000934","MC_PC_U127527180","R37HL051021","U01HG004446","TW008288","1R01AG032098-01A","R01 HL105756","RR20649","G0400874","DK56350","MOP-82810","G0500539","N01-HC-25195","P01CA087969","090532","R01 HL086694-05","R01HL071205","RG/07/008/23674","R01 HL086694-03","5R01HL08770002","R01 HL088120","G1000143","MC_UP_A100_1003","P30 ES010126","HL-87660","ES10126","R01 HL088119","N01-AG-12100","U01 DK062418","DK063491","R01 DK072193","G0700931","N01-HC-55021","N01-HC-55020","R01HL060894","N01-HC-55022","N01-AG-1-2109","MOP77682","P 20545","N01 HC-95169","G0601966","SP/08/005/25115","HL098283","N01-HC-55018","N01-HC-55016","N01-HC-55015","U01HG004415","M01-RR00425","N01-HC-55019","N01 HC-95159","MC_U127561128","RP24/2/2006","TW05596","U01HG004402","RG08/01","G0401527","U10 HL054512","070191/Z/03/Z","U54 RR020278"],"pubmed_authors":["Kleefstra N","Lightstone L","Tomaszewski M","Wichmann HE","Wain LV","Uitterlinden AG","Stark K","Wilensky R","Wurtz P","Navis G","Ebrahim S","Zhao JH","Thelle DS","Olden M","Bilo HJ","Tonjes A","Singleton A","Kita Y","Aragam J","Bornstein SR","Munzel T","Schwartz SM","Groop L","Walker M","Zemunik T","Kottgen A","Kathiresan S","Wang YA","Knowles J","Bolton JA","Munzel TF","Heath S","Vineis P","Caulfield MJ","Chaturvedi N","Soininen P","Klopp N","Sidney S","Fisher M","Levy D","McArdle WL","Kulkarni SR","Preuss M","Thorsteinsdottir U","Zeller T","Elliot P","Arnett D","Jackson AU","Heid IM","Ongen H","Blankenberg S","Fox CS","Najjar S","Khaw KT","Munroe PB","Emilsson V","Aspelund T","Howard P","Wong A","de Andrade M","Gale DP","Smith AV","Yajnik CS","Corsi AM","Raffel LJ","Rasheed A","Iribarren C","Ridker PM","Taylor KD","Redfield MM","Charchar FJ","Salako T","Bonnycastle LL","Zhu H","Rivadeneira F","Volker U","Milaneschi Y","Kuusisto J","Chen MH","Johansson A","Fox ER","Ruokonen A","Zhu X","Mohlke KL","Perola M","Roderick PJ","Beckmann J","Lackner KJ","Dandona S","Dong Y","Roberts R","Andersen K","Willerson JT","Hilton G","Pihur V","Wilson JF","Miki T","Kuh D","Schalling M","Prokopenko I","Folsom A","Rosamond WD","Struchalin M","Meinitzer A","Hernandez D","Gieger C","Sharma P","Hu FB","Perucha E","Magi R","Nelson C","Wilde S","Sinning C","Chen L","Nordfors L","Onland-Moret NC","Kahonen M","Shuldiner AR","Garcia M","Gyllensten UB","Badola S","Jarvelin MR","Aulchenko Y","Lawlor DA","Islam M","Guiducci C","EchoGen consortium","Smit JH","Plump A","van Gilst WH","Haritunians T","Marz W","Quertermous T","Lumley T","Ketkar S","Kivimaki M","Homan van der Heide JJ","Johnson T","Illig T","Liu Y","de Jong PE","Lind L","Siscovick D","Pattaro C","Grassler J","Johnson A","Nauck M","Veldre G","Hernandez-Fuentes M","Stringham HM","Winkelmann BR","Homuth G","O'Donnell CJ","Harris T","Grobbee DE","Province M","Snieder H","Whincup PH","Palmen J","Ball SG","Burtt N","Terzic J","Launer LJ","Seielstad M","Newton-Cheh C","Morris RW","Wass MN","Hypponen E","Lathrop M","Zgaga L","Parsa A","Volzke H","Epstein S","Guo X","Scharnagl H","van der Schouw YT","Platou CG","Bruse P","Chasman DI","Hengstenberg C","Atkinson EJ","Rettig R","Gabriel SB","Frayling TM","Peden JF","CKDGen Consortium","Dehghan A","Risch N","Tayo B","Pare G","Stenvinkel P","Rodeheffer RJ","Dimkovic T","Kullo I","Hall AS","Staessen JA","Adeyemo A","Harris TB","Cornelis MC","Proust C","Hoffmann M","Hardy R","Laakso M","Curhan GC","Bergmann S","Voight BF","Nalls MA","Borecki I","Vasan R","Zitting P","Han X","Franke A","Jarinova O","KidneyGen Consortium","Lohman KK","Lapsley M","Bochud M","Galan P","Deloukas P","Schillert A","Lohman K","Kong A","Qu L","Hofman A","Luttropp K","Wareham NJ","Burton PR","Benjamin EJ","Dobnig H","Stritzke J","Loley C","Minelli C","Org E","Heckbert SR","Tzoulaki I","Coresh J","Arking DE","Scott LJ","Beilby JP","Shrine NR","Knouf CW","Murabito J","Tukiainen T","Peltonen L","Freyer J","Devuyst O","Johnson AD","Musunuru K","Medack A","Clarke R","Elliott P","Rampersaud E","Schmidt H","Schmidt R","Vartiainen E","Willenborg C","Schunkert H","Meitinger T","Talmud PJ","Renner W","Barroso I","Yao J","Shlipak MG","Giallauria F","Pilz S","Sober S","Gaunt TR","Casas JP","Kollerits B","Waeber G","Kinra S","Gyllensten U","Volcik K","Han BG","Zweiker R","Tuomilehto J","Gao X","Mani KR","Ahmadi KR","McKenzie CA","Wild SH","Schnabel RB","Bis J","Ingelsson E","Denniff M","Alexander M","Bots ML","Tabara Y","Fuchsberger C","O'Reilly PF","CHARGE-HF consortium","Sun YV","Fortmann S","Waterworth DM","Jafar TH","Pramstaller PP","Chen IY","Metter J","Kramer BK","Waterworth D","Day IN","Ohkubo T","Kroemer HK","Kim HL","van der Harst P","Shaw-Hawkins S","Kovacs P","Rudan I","Ogihara T","Nyberg F","Zhai G","Koenig W","Lord GM","Smith A","Rao DC","Vitart V","Hadley D","Chambers JC","Smith N","Halperin E","Hakonarson HH","Brandstatter A","Deckers JW","Turne ST","Connell JM","Scuteri A","Nguyen KD","Doumatey A","Nilsson P","Kumari M","Cupples LA","Psaty BM","Uiterwaal CS","Narisu N","Cooper RS","Leak TS","Hepkema BG","Kumar MV","Zukowska-Szczechowska E","Eyheramendy S","Deng G","Luan J","Schlieper G","Soler Artigas M","Kangas AJ","Schreiber S","Stancakova A","Mosley TH","Wiggins KL","Ong RT","Laaksonen R","Ubink-Veltmaat LJ","Stewart AF","Taylor A","Parker AN","Umemura S","Loos RJ","Devaney J","Palmas W","Hedblad B","Morrison A","Werdan K","Watkins H","Rudock ME","Lyytikainen LP","Cho YS","Felix JF","Langefeld CD","Tiret L","Konig IR","Gretarsdottir S","Lakatta EG","Holm H","Weder AB","Collins FS","Boger CA","Altshuler D","Waksman R","Matullo G","Kardia SL","Janipalli CS","de Boer J","Marciante K","Hartikainen AL","Bohm BO","Gottdiener JS","Ziegler A","Hwang SJ","Wagenknecht LE","Watzinger N","Eiriksdottir G","Pichard AD","Prabhakaran D","Meschia JF","Mattha W","Zerres K","Brown MJ","Ramachandran V","Hlatky M","Kettunen J","Fava C","Reffelmann T","Laitinen J","Okamura T","Dominiczak A","Bis JC","Boehnke M","Witteman JC","Zillikens MC","Wild PS","Vollenweider P","Schnabel R","Boban M","Nicaud V","Grosshennig A","Launer L","Mitchell BD","Haerting J","Kleber M","Demissie S","Bakker SJ","Peters A","Rotter JI","Viikari J","Thorleifsson G","Reilly MP","Folsom AR","Cotlarciuc I","Pouta A","Shriner D","Sanna S","Kronenberg F","Loehr LR","Hercberg S","Absher D","Arora P","Nahrstedt J","Kuznetsova T","Sternberg MJ","Nitsch D","Aulchenko YS","Brand E","Imboden M","Meisinger C","Sijbrands EJ","Fowkes FG","Satler L","Li M","van Duijn CM","International Consortium for Blood Pressure Genome-Wide Association Studies","Rotimi C","Cambien F","Lagou V","Li Y","Samani NJ","Davey Smith G","Assimes TL","Wallace C","Ehret GB","Ludwig B","Linsel-Nitschke P","Blettner M","Scott J","Kent KM","Smith NL","Danesh J","Chang YP","Mangino M","Chandak GR","Feitosa M","Kooner JS","Rochat T","de Silva R","Stricker B","Lackner K","Burnett MS","Hingorani AD","Marechal C","Ricceri F","Zhang W","Ala-Korpela M","Stojakovic T","Friedrich N","Saleheen D","Bergman RN","Meneton P","Cavalieri M","Tripathy V","McCarthy MI","Zhang F","Vinay DG","Siscovick DS","Melander O","Rice K","Go A","Gudnason V","Verwoert GC","Morrison AC","Tai ES","Kedenko L","Larson MG","Lucas G","Mitchell GF","Lee NR","Lieb W","Floege J","Ikram MA","Uitterlinden A","Laan M","Stricker BH","Kao WH","O'Connell JR","Guarrera S","Hayward C","Felix SB","Forouhi NG","Palmer LJ","Aherrahrou Z","Tomaschitz A","Raitakari O","Gulde S","Lindsay JM","Meyers R","Cook HT","Tobin MD","Rosengren A","Amin N","Erdmann J","Salomaa V","Tang H","Whitteman J","Tanaka T","Wells GA","Probst-Hensch NM","McPherson R","Swaminathan R","Grammer TB","Goel A","Rice KM","Penninx BW","Young JH","Ganesh SK","Lee JY","Zelenika D","Palmer ND","Demirkan A","Lawrence RW","Swift AJ","Mattace-Raso FU","Dreisbach AW","Balmforth AJ","Hunt SC","Winkler K","Beckmann JS","Teumer A","Shi G","Orru M","Cooper JA","Hicks AA","Schwarz PE","Braund PS","Wright BJ","Stefansson K","Kolcic I","Boerwinkle E","Abecasis GR","CARDIoGRAM consortium","Igl W","Gulcher JR","Hveem K","Demissie-Banjaw S","Wang TJ","Stumvoll M","Spector TD","Ferrucci L","Perret C","Glazer N","Bragg-Gresham JL","Marmot MG","Wang W","Hopewell JC","Wang X","Seelen MA","Oostra BA","Wu Y","Sjogren M","Vasan RS","Wright AF","Sehmi JS","Endlich K","Go MJ","Ueshima H","Wong TY","Farrall M","Dockrell M","Mooser V","Thorgeirsson G","Hamsten A","Yang Q","Gansevoort RT","Adair LS","Rader DJ","Dorr M","Doering A","Polasek O","Morken MA","Dikkeschei LD","Heckbert S","Rupprecht HJ","van Duijn C","Greiser KH","Maxwell PH","Bandinelli S","Steinle NI","Isaacs A","Dominiczak AF","Schlessinger D","Zaboli G","Forrester T","Soranzo N","Lehtimaki T","Chakravarti A","Uda M","Brand SM","Cooper MN","Dahgam S","Thompson JR","Hastie N","Bickel C","Iwai N","Strachan DP","Benjamin E","Campbell S","Ellinghaus D","Sim X","Elosua R","Barbalic M","Longstreth WT","Seshadri S","Campbell H","Chang PP","Smith GD","Wild P","Humphries SE","Viigimaa M","Glazer NL","Couper D","Eggermann T","Paulweber B"],"additional_accession":[]},"is_claimable":false,"name":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.","description":"Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Sep","modification":"2024-11-06T14:33:23.822Z","creation":"2019-03-27T00:52:55Z"},"accession":"S-EPMC3340926","cross_references":{"pubmed":["21909115"],"doi":["10.1038/nature10405"]}}