{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Park KW"],"pubmed_abstract":["<h4>Background</h4>Second-generation drug-eluting stents (DES) have raised the bar of clinical performance. These stents are mostly made from cobalt chromium alloy. A newer generation DES has been developed from platinum chromium alloy, but clinical data regarding the efficacy and safety of the platinum chromium-based everolimus-eluting stent (PtCr-EES) is limited, with no comparison data against the cobalt chromium-based zotarolimus-eluting stent (CoCr-ZES). In addition, an antiplatelet regimen is an integral component of medical therapy after percutaneous coronary intervention (PCI). A 1-week duration of doubling the dose of clopidogrel (double-dose antiplatelet therapy (DDAT)) was shown to improve outcome at 1 month compared with conventional dose in acute coronary syndrome (ACS) patien"],"journal":["Trials"],"pagination":["29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3342216"],"repository":["biostudies-literature"],"pubmed_title":["The 'Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & effectiveneSS of drug-elUting stents & antiplatelet REgimen' (HOST-ASSURE) trial: study protocol for a randomized controlled trial."],"pmcid":["PMC3342216"],"pubmed_authors":["Shin ES","HOST investigators","Park JJ","Hwang KK","Kwon HM","Chae IH","Park BE","Kim HS","Yoon JH","Oh JH","Kang SH","Kim S","Park KW","Moon KW","Lee SY","Cha KS","Park TH","Rhew JY","Jeon HK","Jeong MH","Lee SP"],"additional_accession":[]},"is_claimable":false,"name":"The 'Harmonizing Optimal Strategy for Treatment of coronary artery stenosis - sAfety & effectiveneSS of drug-elUting stents & antiplatelet REgimen' (HOST-ASSURE) trial: study protocol for a randomized controlled trial.","description":"<h4>Background</h4>Second-generation drug-eluting stents (DES) have raised the bar of clinical performance. These stents are mostly made from cobalt chromium alloy. A newer generation DES has been developed from platinum chromium alloy, but clinical data regarding the efficacy and safety of the platinum chromium-based everolimus-eluting stent (PtCr-EES) is limited, with no comparison data against the cobalt chromium-based zotarolimus-eluting stent (CoCr-ZES). In addition, an antiplatelet regimen is an integral component of medical therapy after percutaneous coronary intervention (PCI). A 1-week duration of doubling the dose of clopidogrel (double-dose antiplatelet therapy (DDAT)) was shown to improve outcome at 1 month compared with conventional dose in acute coronary syndrome (ACS) patien","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2026-04-07T17:49:05.964Z","creation":"2019-03-27T00:52:56Z"},"accession":"S-EPMC3342216","cross_references":{"pubmed":["22463698"],"doi":["10.1186/1745-6215-13-29"]}}