biostudies-literatureRemeseiro SNIGMS NIH HHS2076-89https://www.ebi.ac.uk/biostudies/studies/S-EPMC3343459biostudies-literatureUnknown31(9)Cohesin is a protein complex originally identified for its role in sister chromatid cohesion, although increasing evidence portrays it also as a major organizer of interphase chromatin. Vertebrate cohesin consists of Smc1, Smc3, Rad21/Scc1 and either stromal antigen 1 (SA1) or SA2. To explore the functional specificity of these two versions of cohesin and their relevance for embryonic development and cancer, we generated a mouse model deficient for SA1. Complete ablation of SA1 results in embryonic lethality, while heterozygous animals have shorter lifespan and earlier onset of tumourigenesis. SA1-null mouse embryonic fibroblasts show decreased proliferation and increased aneuploidy as a result of chromosome segregation defects. These defects are not caused by impaired centromeric cohesionThe EMBO journalCohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.PMC3343459R01 GM045751GM045751Drosopoulos WCRemeseiro SCarretero MMartinez PCanamero MSchildkraut CLCuadrado ABlasco MALosada AfalseCohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.Cohesin is a protein complex originally identified for its role in sister chromatid cohesion, although increasing evidence portrays it also as a major organizer of interphase chromatin. Vertebrate cohesin consists of Smc1, Smc3, Rad21/Scc1 and either stromal antigen 1 (SA1) or SA2. To explore the functional specificity of these two versions of cohesin and their relevance for embryonic development and cancer, we generated a mouse model deficient for SA1. Complete ablation of SA1 results in embryonic lethality, while heterozygous animals have shorter lifespan and earlier onset of tumourigenesis. SA1-null mouse embryonic fibroblasts show decreased proliferation and increased aneuploidy as a result of chromosome segregation defects. These defects are not caused by impaired centromeric cohesion2012-01-01T00:00:00Z2012 May2025-04-04T09:12:49.028Z2019-03-27T00:53:01ZS-EPMC33434592241536510.1038/emboj.2012.11