{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["68(Pt 4)"],"submitter":["Xie L"],"pubmed_abstract":["The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å(3) solvent-accessible voids."],"journal":["Acta crystallographica. Section E, Structure reports online"],"pagination":["o1206-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3344143"],"repository":["biostudies-literature"],"pubmed_title":["41-Azido-41-de-oxy-rapamycin."],"pmcid":["PMC3344143"],"pubmed_authors":["Huang J","Zuo J","Xie L","Yu H","Cheng Y"],"additional_accession":[]},"is_claimable":false,"name":"41-Azido-41-de-oxy-rapamycin.","description":"The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å(3) solvent-accessible voids.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Apr","modification":"2025-04-04T09:12:34.617Z","creation":"2019-03-27T00:53:04Z"},"accession":"S-EPMC3344143","cross_references":{"pubmed":["22606146"],"doi":["10.1107/S1600536812012548"]}}