biostudies-literatureUnknown7(5)Herold CDopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-time RT-PCR analysis of dopamine receptor expression in pigeons to identify molecular changes that accompany training of isolated cognitive subfunctions. In birds, the D1-like receptor family is extended and consists of the D1A, D1B, and D1D receptors. Our data show that D1B receptor plasticity follows a training that includes active mental maintenance of information, whereas D1A and D1D receptor plasticity in addition accompanies learning of stimulus-response associations. Plasticity of D1-like rePloS onee36484https://www.ebi.ac.uk/biostudies/studies/S-EPMC3344878biostudies-literaturePlasticity in D1-like receptor expression is associated with different components of cognitive processes.PMC3344878Herold CJoshi IHollmann MGunturkun OChehadi OfalsePlasticity in D1-like receptor expression is associated with different components of cognitive processes.Dopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-time RT-PCR analysis of dopamine receptor expression in pigeons to identify molecular changes that accompany training of isolated cognitive subfunctions. In birds, the D1-like receptor family is extended and consists of the D1A, D1B, and D1D receptors. Our data show that D1B receptor plasticity follows a training that includes active mental maintenance of information, whereas D1A and D1D receptor plasticity in addition accompanies learning of stimulus-response associations. Plasticity of D1-like re2012-01-01T00:00:00Z20122025-04-26T04:21:06.813Z2019-03-26T23:18:37ZS-EPMC33448782257416910.1371/journal.pone.0036484