{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Makarova JA"],"pubmed_abstract":["<h4>Background</h4>Small nucleolar RNAs (snoRNAs) are a large group of non-coding RNAs (ncRNAs) that mainly guide 2'-O-methylation (C/D RNAs) and pseudouridylation (H/ACA RNAs) of ribosomal RNAs. The pattern of rRNA modifications and the set of snoRNAs that guide these modifications are conserved in vertebrates. Nearly all snoRNA genes in vertebrates are localized in introns of other genes and are processed from pre-mRNAs. Thus, the same promoter is used for the transcription of snoRNAs and host genes.<h4>Results</h4>The series of studies by Dahai Zhu and coworkers on snoRNAs and their genes were critically considered. We present evidence that dozens of species-specific snoRNAs that they described in vertebrates are experimental artifacts resulting from the improper use of Northern hybridi"],"journal":["BMC genomics"],"pagination":["543"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3349704"],"repository":["biostudies-literature"],"pubmed_title":["SNOntology: Myriads of novel snoRNAs or just a mirage?"],"pmcid":["PMC3349704"],"pubmed_authors":["Makarova JA","Kramerov DA"],"additional_accession":[]},"is_claimable":false,"name":"SNOntology: Myriads of novel snoRNAs or just a mirage?","description":"<h4>Background</h4>Small nucleolar RNAs (snoRNAs) are a large group of non-coding RNAs (ncRNAs) that mainly guide 2'-O-methylation (C/D RNAs) and pseudouridylation (H/ACA RNAs) of ribosomal RNAs. The pattern of rRNA modifications and the set of snoRNAs that guide these modifications are conserved in vertebrates. Nearly all snoRNA genes in vertebrates are localized in introns of other genes and are processed from pre-mRNAs. Thus, the same promoter is used for the transcription of snoRNAs and host genes.<h4>Results</h4>The series of studies by Dahai Zhu and coworkers on snoRNAs and their genes were critically considered. We present evidence that dozens of species-specific snoRNAs that they described in vertebrates are experimental artifacts resulting from the improper use of Northern hybridi","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Nov","modification":"2026-04-08T00:12:29.103Z","creation":"2019-03-27T00:53:21Z"},"accession":"S-EPMC3349704","cross_references":{"pubmed":["22047601"],"doi":["10.1186/1471-2164-12-543"]}}