{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gerloff J"],"funding":["NHLBI NIH HHS"],"pagination":["2134-43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3349833"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["180(5)"],"pubmed_abstract":["Cellular mechanisms of carotid intima-media thickening (IMT) are largely unknown. The receptor tyrosine kinase Axl is essential for function of both bone marrow (BM) and non-BM cells. We studied the mechanisms by which Axl expression in BM-derived cells (compared with non-BM-derived cells) mediates carotid IMT. Partial ligation of the left carotid artery resulted in a similar carotid blood flow reduction in Axl chimeras. Neither irradiation nor bone marrow transplantation had any effect on the 40% difference in carotid IMT between Axl genotypes. Axl-dependent survival is very important for intimal leukocytes; however, Axl expression in BM cells contributes to <30% of carotid IMT. Axl in non-BM cells has a greater effect on carotid remodeling. Expression of Axl in non-BM cells is crucial fo"],"journal":["The American journal of pathology"],"pubmed_title":["Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening."],"pmcid":["PMC3349833"],"funding_grant_id":["R01 HL105623"],"pubmed_authors":["Korshunov VA","Gerloff J"],"additional_accession":[]},"is_claimable":false,"name":"Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.","description":"Cellular mechanisms of carotid intima-media thickening (IMT) are largely unknown. The receptor tyrosine kinase Axl is essential for function of both bone marrow (BM) and non-BM cells. We studied the mechanisms by which Axl expression in BM-derived cells (compared with non-BM-derived cells) mediates carotid IMT. Partial ligation of the left carotid artery resulted in a similar carotid blood flow reduction in Axl chimeras. Neither irradiation nor bone marrow transplantation had any effect on the 40% difference in carotid IMT between Axl genotypes. Axl-dependent survival is very important for intimal leukocytes; however, Axl expression in BM cells contributes to <30% of carotid IMT. Axl in non-BM cells has a greater effect on carotid remodeling. Expression of Axl in non-BM cells is crucial fo","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 May","modification":"2026-05-29T15:52:01.56Z","creation":"2019-03-27T00:53:22Z"},"accession":"S-EPMC3349833","cross_references":{"pubmed":["22538191"],"doi":["10.1016/j.ajpath.2012.01.036"]}}