biostudies-literatureGerloff JNHLBI NIH HHS2134-43https://www.ebi.ac.uk/biostudies/studies/S-EPMC3349833biostudies-literatureUnknown180(5)Cellular mechanisms of carotid intima-media thickening (IMT) are largely unknown. The receptor tyrosine kinase Axl is essential for function of both bone marrow (BM) and non-BM cells. We studied the mechanisms by which Axl expression in BM-derived cells (compared with non-BM-derived cells) mediates carotid IMT. Partial ligation of the left carotid artery resulted in a similar carotid blood flow reduction in Axl chimeras. Neither irradiation nor bone marrow transplantation had any effect on the 40% difference in carotid IMT between Axl genotypes. Axl-dependent survival is very important for intimal leukocytes; however, Axl expression in BM cells contributes to <30% of carotid IMT. Axl in non-BM cells has a greater effect on carotid remodeling. Expression of Axl in non-BM cells is crucial foThe American journal of pathologyImmune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.PMC3349833R01 HL105623Korshunov VAGerloff JfalseImmune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.Cellular mechanisms of carotid intima-media thickening (IMT) are largely unknown. The receptor tyrosine kinase Axl is essential for function of both bone marrow (BM) and non-BM cells. We studied the mechanisms by which Axl expression in BM-derived cells (compared with non-BM-derived cells) mediates carotid IMT. Partial ligation of the left carotid artery resulted in a similar carotid blood flow reduction in Axl chimeras. Neither irradiation nor bone marrow transplantation had any effect on the 40% difference in carotid IMT between Axl genotypes. Axl-dependent survival is very important for intimal leukocytes; however, Axl expression in BM cells contributes to <30% of carotid IMT. Axl in non-BM cells has a greater effect on carotid remodeling. Expression of Axl in non-BM cells is crucial fo2012-01-01T00:00:00Z2012 May2026-05-29T15:52:01.56Z2019-03-27T00:53:22ZS-EPMC33498332253819110.1016/j.ajpath.2012.01.036