{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shipp LE"],"funding":["NICHD NIH HHS"],"pagination":["1111-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3354041"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["241(6)"],"pubmed_abstract":["<h4>Background</h4>ATP-binding cassette (ABC) transporters are membrane proteins that regulate intracellular concentrations of myriad compounds and ions. There are >100 ABC transporter predictions in the Strongylocentrotus purpuratus genome, including 40 annotated ABCB, ABCC, and ABCG \"multidrug efflux\" transporters. Despite the importance of multidrug transporters for protection and signaling, their expression patterns have not been characterized in deuterostome embryos.<h4>Results</h4>Sea urchin embryos expressed 20 ABCB, ABCC, and ABCG transporter genes in the first 58 hr of development, from unfertilized egg to early prism. We quantified transcripts of ABCB1a, ABCB4a, ABCC1, ABCC5a, ABCC9a, and ABCG2b, and found that ABCB1a mRNA was 10-100 times more abundant than other transporter mRN"],"journal":["Developmental dynamics : an official publication of the American Association of Anatomists"],"pubmed_title":["ATP-binding cassette (ABC) transporter expression and localization in sea urchin development."],"pmcid":["PMC3354041"],"funding_grant_id":["R00 HD058070","HD058070","R00 HD058070-05","K99 HD058070"],"pubmed_authors":["Shipp LE","Hamdoun A"],"additional_accession":[]},"is_claimable":false,"name":"ATP-binding cassette (ABC) transporter expression and localization in sea urchin development.","description":"<h4>Background</h4>ATP-binding cassette (ABC) transporters are membrane proteins that regulate intracellular concentrations of myriad compounds and ions. There are >100 ABC transporter predictions in the Strongylocentrotus purpuratus genome, including 40 annotated ABCB, ABCC, and ABCG \"multidrug efflux\" transporters. Despite the importance of multidrug transporters for protection and signaling, their expression patterns have not been characterized in deuterostome embryos.<h4>Results</h4>Sea urchin embryos expressed 20 ABCB, ABCC, and ABCG transporter genes in the first 58 hr of development, from unfertilized egg to early prism. We quantified transcripts of ABCB1a, ABCB4a, ABCC1, ABCC5a, ABCC9a, and ABCG2b, and found that ABCB1a mRNA was 10-100 times more abundant than other transporter mRN","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jun","modification":"2025-04-26T21:11:12.695Z","creation":"2019-03-26T22:30:25Z"},"accession":"S-EPMC3354041","cross_references":{"pubmed":["22473856"],"doi":["10.1002/dvdy.23786"]}}