{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang J"],"funding":["NCRR NIH HHS","NIAID NIH HHS","NIH HHS"],"pagination":["e37019"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3355165"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(5)"],"pubmed_abstract":["Adjuvants potentiate antigen-specific protective immune responses and can be key elements promoting vaccine effectiveness. We previously reported that the Onchocerca volvulus recombinant protein rOv-ASP-1 can induce activation and maturation of naïve human DCs and therefore could be used as an innate adjuvant to promote balanced Th1 and Th2 responses to bystander vaccine antigens in mice. With a few vaccine antigens, it also promoted a Th1-biased response based on pronounced induction of Th1-associated IgG2a and IgG2b antibody responses and the upregulated production of Th1 cytokines, including IL-2, IFN-γ, TNF-α and IL-6. However, because it is a protein, the rOv-ASP-1 adjuvant may also induce anti-self-antibodies. Therefore, it was important to verify that the host responses to self will"],"journal":["PloS one"],"pubmed_title":["The adjuvanticity of an O. volvulus-derived rOv-ASP-1 protein in mice using sequential vaccinations and in non-human primates."],"pmcid":["PMC3355165"],"funding_grant_id":["R01 AI068002","P51 OD011104","P51 RR00164-50","P51 RR000164"],"pubmed_authors":["Lu L","Liu J","Tricoche N","Goud G","Marx PA","Zhan B","Hunter M","Jiang S","Wang J","Du L","Lustigman S","Didier ES"],"additional_accession":[]},"is_claimable":false,"name":"The adjuvanticity of an O. volvulus-derived rOv-ASP-1 protein in mice using sequential vaccinations and in non-human primates.","description":"Adjuvants potentiate antigen-specific protective immune responses and can be key elements promoting vaccine effectiveness. We previously reported that the Onchocerca volvulus recombinant protein rOv-ASP-1 can induce activation and maturation of naïve human DCs and therefore could be used as an innate adjuvant to promote balanced Th1 and Th2 responses to bystander vaccine antigens in mice. With a few vaccine antigens, it also promoted a Th1-biased response based on pronounced induction of Th1-associated IgG2a and IgG2b antibody responses and the upregulated production of Th1 cytokines, including IL-2, IFN-γ, TNF-α and IL-6. However, because it is a protein, the rOv-ASP-1 adjuvant may also induce anti-self-antibodies. Therefore, it was important to verify that the host responses to self will","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-04-25T23:11:06.364Z","creation":"2019-06-05T17:18:19Z"},"accession":"S-EPMC3355165","cross_references":{"pubmed":["22615877"],"doi":["10.1371/journal.pone.0037019"]}}