biostudies-literatureAgusti AMedical Research Councile37483https://www.ebi.ac.uk/biostudies/studies/S-EPMC3356313biostudies-literatureUnknown7(5)<h4>Background</h4>Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552).<h4>Methods and findings</h4>Six inflammatory biomarkers in peripheral blood (white blood cells (WBC) count and CRP, IL-6, IL-8, fibrinogen and TNF-α levels) were quantified in 1,755 COPD patients, 297 smokers with normal spirometry and 202 non-smoker controls that were followed-up for three years. We found that, at baseline, 30% of COPD patients did not show evidence of systemic inflammation whereas 16% hPloS onePersistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.PMC3356313G0901786G0901697Wouters EBakke PWise RYates JIvanov YSilverman EKillian KGreenwald GWanner AKrepelka JSharafkhaneh AKostov KCrim CFitzgerald MRennard SSauleda JCasaburi RYates JCSiler TSchuller DTal-Singer RFeschenko YZuWallack REdwards LEdwards LDSciurba FCelli BMacNee WLevy RAgusti AGiessel GAnzueto ACoxson HOSilverman EKMayer RJYashina LMahler DMake BCoxson HMiller BScanlon PKosnik MBourbeau JHernandez PHanania NCalverley PSingh DCalverley PMVestbo JGotfried MO'Donnell DLomas DQuinn DWedzicha JEvaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) InvestigatorsMaltais FRennard SILomas DAMiller BEGavrisyuk VBraman SRochester CfalsePersistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.<h4>Background</h4>Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552).<h4>Methods and findings</h4>Six inflammatory biomarkers in peripheral blood (white blood cells (WBC) count and CRP, IL-6, IL-8, fibrinogen and TNF-α levels) were quantified in 1,755 COPD patients, 297 smokers with normal spirometry and 202 non-smoker controls that were followed-up for three years. We found that, at baseline, 30% of COPD patients did not show evidence of systemic inflammation whereas 16% h2012-01-01T00:00:00Z20122026-04-29T16:28:18.072Z2026-04-07T15:21:11.764ZS-EPMC33563132262403810.1371/journal.pone.0037483