biostudies-literatureMathieson IWellcome Trust634-41https://www.ebi.ac.uk/biostudies/studies/S-EPMC3359642biostudies-literatureUnknown17(6)Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11?626 cases and 15?237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency >5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia.Molecular psychiatryMeta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.PMC3359642079912050573090532Munafo MRFlint JMathieson IfalseMeta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11?626 cases and 15?237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency >5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia.2012-01-01T00:00:00Z2012 Jun2020-11-08T09:04:28Z2019-03-27T00:53:49ZS-EPMC33596422148343510.1038/mp.2011.41