{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Antonescu CR"],"funding":["NCI NIH HHS"],"pagination":["757-64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3361892"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50(10)"],"pubmed_abstract":["Despite their shared predilection for superficial soft tissue of distal extremities and frequent local recurrences, myxoinflammatory fibroblastic sarcoma (MIFS) and hemosiderotic fibrolipomatous tumor (HFLT) have distinct morphologic appearances. Recent studies have identified an identical t(1;10)(p22;q24) in five cases of MIFS and two of HFLT, as well as common amplifications on 3p11-12. To investigate further their potential relationship and to determine the incidence of t(1;10) in a larger cohort, we subjected seven MIFS, 14 HFLT, and three cases with mixed morphology, to molecular and cytogenetic analysis. Fluorescence in situ hybridization (FISH) analysis for rearrangements of TGFBR3 on 1p22 and of MGEA5 on 10q24 was performed in all cases, whereas the status of VGLL3 gene amplificati"],"journal":["Genes, chromosomes & cancer"],"pubmed_title":["Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor."],"pmcid":["PMC3361892"],"funding_grant_id":["P50 CA140146-01","P01 CA047179-15A2","P01 CA047179","P50 CA140146"],"pubmed_authors":["Antonescu CR","Nielsen GP","Dal Cin P","Zhang L","Fletcher CD","Rosenberg AE"],"additional_accession":[]},"is_claimable":false,"name":"Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor.","description":"Despite their shared predilection for superficial soft tissue of distal extremities and frequent local recurrences, myxoinflammatory fibroblastic sarcoma (MIFS) and hemosiderotic fibrolipomatous tumor (HFLT) have distinct morphologic appearances. Recent studies have identified an identical t(1;10)(p22;q24) in five cases of MIFS and two of HFLT, as well as common amplifications on 3p11-12. To investigate further their potential relationship and to determine the incidence of t(1;10) in a larger cohort, we subjected seven MIFS, 14 HFLT, and three cases with mixed morphology, to molecular and cytogenetic analysis. Fluorescence in situ hybridization (FISH) analysis for rearrangements of TGFBR3 on 1p22 and of MGEA5 on 10q24 was performed in all cases, whereas the status of VGLL3 gene amplificati","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2025-04-04T22:47:54.358Z","creation":"2019-03-27T00:53:56Z"},"accession":"S-EPMC3361892","cross_references":{"pubmed":["21717526"],"doi":["10.1002/gcc.20897"]}}