{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["109(22)"],"submitter":["Henrion U"],"pubmed_abstract":["Voltage-gated ion channels open and close in response to changes in membrane potential, thereby enabling electrical signaling in excitable cells. The voltage sensitivity is conferred through four voltage-sensor domains (VSDs) where positively charged residues in the fourth transmembrane segment (S4) sense the potential. While an open state is known from the Kv1.2/2.1 X-ray structure, the conformational changes underlying voltage sensing have not been resolved. We present 20 additional interactions in one open and four different closed conformations based on metal-ion bridges between all four segments of the VSD in the voltage-gated Shaker K channel. A subset of the experimental constraints was used to generate Rosetta models of the conformations that were subjected to molecular simulation "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["8552-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3365220"],"repository":["biostudies-literature"],"pubmed_title":["Tracking a complete voltage-sensor cycle with metal-ion bridges."],"pmcid":["PMC3365220"],"pubmed_authors":["Renhorn J","Lindahl E","Bjelkmar P","Schwaiger CS","Nelson EM","Borjesson SI","Henrion U","Wallner B","Elinder F"],"additional_accession":[]},"is_claimable":false,"name":"Tracking a complete voltage-sensor cycle with metal-ion bridges.","description":"Voltage-gated ion channels open and close in response to changes in membrane potential, thereby enabling electrical signaling in excitable cells. The voltage sensitivity is conferred through four voltage-sensor domains (VSDs) where positively charged residues in the fourth transmembrane segment (S4) sense the potential. While an open state is known from the Kv1.2/2.1 X-ray structure, the conformational changes underlying voltage sensing have not been resolved. We present 20 additional interactions in one open and four different closed conformations based on metal-ion bridges between all four segments of the VSD in the voltage-gated Shaker K channel. A subset of the experimental constraints was used to generate Rosetta models of the conformations that were subjected to molecular simulation ","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 May","modification":"2026-05-01T23:59:14.221Z","creation":"2025-06-26T03:06:50.461Z"},"accession":"S-EPMC3365220","cross_references":{"pubmed":["22538811"],"doi":["10.1073/pnas.1116938109"]}}