{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["122(6)"],"submitter":["Felcht M"],"pubmed_abstract":["Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and acts as a negative regulator of ANG-1/TIE2 signaling during angiogenesis, thereby controlling the responsiveness of ECs to exogenous cytokines. Recent data from tumors indicate that under certain conditions ANG-2 can also promote angiogenesis. However, the molecular mechanisms of dual ANG-2 functions are poorly understood. Here, we identify a model for the opposing roles of ANG-2 in angiogenesis. We found that angiogenesis-activated endothelium harbored a subpopulation of TIE2-negative ECs (TIE2lo). TIE2 expression was downregulated in angiogenic ECs, which abundantly expressed several integrins. ANG-2 bound to th"],"journal":["The Journal of clinical investigation"],"pagination":["1991-2005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3366398"],"repository":["biostudies-literature"],"pubmed_title":["Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling."],"pmcid":["PMC3366398"],"pubmed_authors":["Besemfelder E","Chavakis E","Kutschera S","Schering A","Vettel C","Kienast Y","Loos EK","Luck R","Terhardt D","Goerdt S","Bartels S","Seidel P","Klein C","Thomas M","Hu J","Appak S","Bartol A","Uemura A","Felcht M","Srivastava K","Wieland T","Augustin HG"],"additional_accession":[]},"is_claimable":false,"name":"Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.","description":"Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and acts as a negative regulator of ANG-1/TIE2 signaling during angiogenesis, thereby controlling the responsiveness of ECs to exogenous cytokines. Recent data from tumors indicate that under certain conditions ANG-2 can also promote angiogenesis. However, the molecular mechanisms of dual ANG-2 functions are poorly understood. Here, we identify a model for the opposing roles of ANG-2 in angiogenesis. We found that angiogenesis-activated endothelium harbored a subpopulation of TIE2-negative ECs (TIE2lo). TIE2 expression was downregulated in angiogenic ECs, which abundantly expressed several integrins. ANG-2 bound to th","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jun","modification":"2025-04-03T22:33:47.57Z","creation":"2019-03-27T00:54:07Z"},"accession":"S-EPMC3366398","cross_references":{"pubmed":["22585576"],"doi":["10.1172/JCI58832","10.1172/jci58832"]}}