{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Scott DW"],"funding":["CCR NIH HHS","NCI NIH HHS","CIHR"],"pagination":["4949-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3367896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(21)"],"pubmed_abstract":["Recently, the landscape of single base mutations in diffuse large B-cell lymphoma (DLBCL) was described. Here we report the discovery of a gene fusion between TBL1XR1 and TP63, the only recurrent somatic novel gene fusion identified in our analysis of transcriptome data from 96 DLBCL cases. Based on this cohort and a further 157 DLBCL cases analyzed by FISH, the incidence in de novo germinal center B cell-like (GCB) DLBCL is 5% (6 of 115). The fusion appears exclusive to GCB and was not seen in 138 non-GCB cases examined (P = .008, Fisher exact test) but was present at low incidence in follicular lymphoma (1 of 81). In all 7 cases identified, the 3' end of the fusion consists of exons 4 and onwards of TP63. The recurrence, subtype enrichment, and the remarkably conserved nature of the TP63"],"journal":["Blood"],"pubmed_title":["TBL1XR1/TP63: a novel recurrent gene fusion in B-cell non-Hodgkin lymphoma."],"pmcid":["PMC3367896"],"funding_grant_id":["HHSN261200800001E","P50 CA130805","HHSN261200800001C","U01 CA114778","1U01CA114778","P50CA130805-01"],"pubmed_authors":["Tan KL","Mungall AJ","Ben-Neriah S","Connors JM","Chan FC","Mungall KL","Slack GW","Morin RD","Rogic S","Steidl C","Marra MA","Scott DW","Gascoyne RD","Lim RS"],"additional_accession":[]},"is_claimable":false,"name":"TBL1XR1/TP63: a novel recurrent gene fusion in B-cell non-Hodgkin lymphoma.","description":"Recently, the landscape of single base mutations in diffuse large B-cell lymphoma (DLBCL) was described. Here we report the discovery of a gene fusion between TBL1XR1 and TP63, the only recurrent somatic novel gene fusion identified in our analysis of transcriptome data from 96 DLBCL cases. Based on this cohort and a further 157 DLBCL cases analyzed by FISH, the incidence in de novo germinal center B cell-like (GCB) DLBCL is 5% (6 of 115). The fusion appears exclusive to GCB and was not seen in 138 non-GCB cases examined (P = .008, Fisher exact test) but was present at low incidence in follicular lymphoma (1 of 81). In all 7 cases identified, the 3' end of the fusion consists of exons 4 and onwards of TP63. The recurrence, subtype enrichment, and the remarkably conserved nature of the TP63","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 May","modification":"2026-06-04T00:48:32.805Z","creation":"2025-08-21T09:50:39.986Z"},"accession":"S-EPMC3367896","cross_references":{"pubmed":["22496164"],"doi":["10.1182/blood-2012-02-414441"]}}