biostudies-literatureScott DWCCR NIH HHSNCI NIH HHSCIHR4949-52https://www.ebi.ac.uk/biostudies/studies/S-EPMC3367896biostudies-literatureUnknown119(21)Recently, the landscape of single base mutations in diffuse large B-cell lymphoma (DLBCL) was described. Here we report the discovery of a gene fusion between TBL1XR1 and TP63, the only recurrent somatic novel gene fusion identified in our analysis of transcriptome data from 96 DLBCL cases. Based on this cohort and a further 157 DLBCL cases analyzed by FISH, the incidence in de novo germinal center B cell-like (GCB) DLBCL is 5% (6 of 115). The fusion appears exclusive to GCB and was not seen in 138 non-GCB cases examined (P = .008, Fisher exact test) but was present at low incidence in follicular lymphoma (1 of 81). In all 7 cases identified, the 3' end of the fusion consists of exons 4 and onwards of TP63. The recurrence, subtype enrichment, and the remarkably conserved nature of the TP63BloodTBL1XR1/TP63: a novel recurrent gene fusion in B-cell non-Hodgkin lymphoma.PMC3367896HHSN261200800001EP50 CA130805HHSN261200800001CU01 CA1147781U01CA114778P50CA130805-01Tan KLMungall AJBen-Neriah SConnors JMChan FCMungall KLSlack GWMorin RDRogic SSteidl CMarra MAScott DWGascoyne RDLim RSfalseTBL1XR1/TP63: a novel recurrent gene fusion in B-cell non-Hodgkin lymphoma.Recently, the landscape of single base mutations in diffuse large B-cell lymphoma (DLBCL) was described. Here we report the discovery of a gene fusion between TBL1XR1 and TP63, the only recurrent somatic novel gene fusion identified in our analysis of transcriptome data from 96 DLBCL cases. Based on this cohort and a further 157 DLBCL cases analyzed by FISH, the incidence in de novo germinal center B cell-like (GCB) DLBCL is 5% (6 of 115). The fusion appears exclusive to GCB and was not seen in 138 non-GCB cases examined (P = .008, Fisher exact test) but was present at low incidence in follicular lymphoma (1 of 81). In all 7 cases identified, the 3' end of the fusion consists of exons 4 and onwards of TP63. The recurrence, subtype enrichment, and the remarkably conserved nature of the TP632012-01-01T00:00:00Z2012 May2026-06-04T00:48:32.805Z2025-08-21T09:50:39.986ZS-EPMC33678962249616410.1182/blood-2012-02-414441