biostudies-literatureSahn JJNIGMS NIH HHS6855-6858https://www.ebi.ac.uk/biostudies/studies/S-EPMC3375694biostudies-literatureUnknown52(51)A multicomponent assembly process (MCAP) was utilized to prepare versatile intermediates that are suitably functionalized for subsequent cyclizations via Ullmann and Heck reactions to efficiently construct substituted 2,6-methanobenzo[b][1,5]oxazocines and 1,6-methanobenzo[c]azocines, respectively. The intramolecular Ullmann cyclization was conducted in tandem with an intermolecular arylation that enabled the rapid syntheses of a number of O-functionalized methanobenzoxazocines.Tetrahedron lettersFacile Syntheses of Substituted, Conformationally-Constrained Benzoxazocines and Benzazocines via Sequential Multicomponent Assembly and Cyclization.PMC3375694R01 GM025439P41 GM086192-02P41 GM086192-03R01 GM025439-27P41 GM086192-01P41 GM086192Martin SFSahn JJfalseFacile Syntheses of Substituted, Conformationally-Constrained Benzoxazocines and Benzazocines via Sequential Multicomponent Assembly and Cyclization.A multicomponent assembly process (MCAP) was utilized to prepare versatile intermediates that are suitably functionalized for subsequent cyclizations via Ullmann and Heck reactions to efficiently construct substituted 2,6-methanobenzo[b][1,5]oxazocines and 1,6-methanobenzo[c]azocines, respectively. The intramolecular Ullmann cyclization was conducted in tandem with an intermolecular arylation that enabled the rapid syntheses of a number of O-functionalized methanobenzoxazocines.2011-01-01T00:00:00Z2011 Dec2024-11-09T14:38:22.01Z2019-03-27T00:54:32ZS-EPMC33756942271193910.1016/j.tetlet.2011.10.022