biostudies-literatureMa MWNCI NIH HHS849-58https://www.ebi.ac.uk/biostudies/studies/S-EPMC3379800biostudies-literatureUnknown14(7)Melanoma brain metastasis that develops as the isolated first visceral site challenges the current paradigm of tumor progression in which brain metastasis is regarded as the final stage. Here we test the hypothesis that melanoma patients who develop brain metastasis as the isolated first visceral site have distinct clinicopathological features at the time of primary melanoma diagnosis. Cutaneous melanoma patients enrolled in 2 prospectively collected databases were studied (Cohort 1: 1972-1982, Cohort 2: 2002-2009). Patients who developed brain metastasis as isolated first visceral site were compared with (1) all other patients, (2) patients who developed visceral metastasis: extracranial only or extracranial and brain, and (3) patients who progressed to other isolated visceral sites firstNeuro-oncologyChallenging the current paradigm of melanoma progression: brain metastasis as isolated first visceral site.PMC33798005P30CA016087Golfinos JGParker ECDarvishian FShao YShapiro RLPavlick ACHernando EOsman IBerman RSLackaye DJMa MWQian MfalseChallenging the current paradigm of melanoma progression: brain metastasis as isolated first visceral site.Melanoma brain metastasis that develops as the isolated first visceral site challenges the current paradigm of tumor progression in which brain metastasis is regarded as the final stage. Here we test the hypothesis that melanoma patients who develop brain metastasis as the isolated first visceral site have distinct clinicopathological features at the time of primary melanoma diagnosis. Cutaneous melanoma patients enrolled in 2 prospectively collected databases were studied (Cohort 1: 1972-1982, Cohort 2: 2002-2009). Patients who developed brain metastasis as isolated first visceral site were compared with (1) all other patients, (2) patients who developed visceral metastasis: extracranial only or extracranial and brain, and (3) patients who progressed to other isolated visceral sites first2012-01-01T00:00:00Z2012 Jul2025-04-22T07:06:23.657Z2019-03-27T00:54:45ZS-EPMC33798002256179910.1093/neuonc/nos113