{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rogulja D"],"funding":["NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["1617-21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3380085"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["335(6076)"],"pubmed_abstract":["How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior."],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Control of sleep by cyclin A and its regulator."],"pmcid":["PMC3380085"],"funding_grant_id":["R37 GM054339","R01 NS053087","R37 NS053087","R01 GM054339","NS053087","GM054339"],"pubmed_authors":["Young MW","Rogulja D"],"additional_accession":[]},"is_claimable":false,"name":"Control of sleep by cyclin A and its regulator.","description":"How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Mar","modification":"2025-04-04T02:37:33.472Z","creation":"2019-03-27T00:54:45Z"},"accession":"S-EPMC3380085","cross_references":{"pubmed":["22461610"],"doi":["10.1126/science.1212476"]}}