biostudies-literatureRogulja DNINDS NIH HHSNIGMS NIH HHS1617-21https://www.ebi.ac.uk/biostudies/studies/S-EPMC3380085biostudies-literatureUnknown335(6076)How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior.Science (New York, N.Y.)Control of sleep by cyclin A and its regulator.PMC3380085R37 GM054339R01 NS053087R37 NS053087R01 GM054339NS053087GM054339Young MWRogulja DfalseControl of sleep by cyclin A and its regulator.How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior.2012-01-01T00:00:00Z2012 Mar2025-04-04T02:37:33.472Z2019-03-27T00:54:45ZS-EPMC33800852246161010.1126/science.1212476