{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Namjou B"],"funding":["BLRD VA","NICHD NIH HHS","NCATS NIH HHS","NCRR NIH HHS","NIDDK NIH HHS","NIAID NIH HHS","NCI NIH HHS","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["1960-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3380425"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(6)"],"pubmed_abstract":["<h4>Objective</h4>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development.<h4>Methods</h4>Fifteen single-nucleotide polymorphisms (SNPs) across TRAF6 were evaluated in 7,490 SLE patients and 6,780 control subjects from different ancestries. Population-based case-control association analyses and meta-analyses were performed. P values, false discovery rate q values, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.<h4>Results</h4>Evidence of associatio"],"journal":["Arthritis and rheumatism"],"pubmed_title":["Evaluation of TRAF6 in a large multiancestral lupus cohort."],"pmcid":["PMC3380425"],"funding_grant_id":["R01 AR044804","P20 RR015577","UL1 TR000154","P30 RR031152","P20-RR-015577","UL1-RR-025741","P60 AR062755","R01 CA141700","K24-AR-002138","R01 AI063622","I01 BX003850","K24 AI078004","P60-AR-049459","UL1 RR024999","P60 AR049459","UL1 RR025005","5UL1-RR-025777","N01-AR-062277","P30 AR053483","M01 RR000079","AR-058554","P30 DK042086","U19-AI-082714","P60-AR-053308","R01 AR052300","UL1 RR029882","R21 AI070304","CA-141700-01","P60 AR030692","P50-AR-048940","AI-063622","P30-DK-42086","UL1-RR-024999","R01 AR043274","R01 AR042460","UL1 RR025777","R21-AI-070304","T32 GM063483","P50 AR048940","AR-043814","P01-AR-049084","L30 AI071651","RR-031152","T32 HD007463","UL1-RR-029882","AR-052300","P20-RR-020143","R01 AR042525","R01 AR043814","K08-AI-083790","U19 AI082714","AR-043274","N01 AR062277","GM-063483","UL1-RR-025005","R01-AR-33062","AR-060366","AI-071651","AR-053483","UL1 RR025741","R37 AI024717","P01-AI-083194","P60-2-AR-030692","P60 AR053308","UL1 TR000062","R01 AR033062","RC1 AR058554","R01 AR057172","R01 AR043727","AR-43727","K08 AI083790","R37-AI-024717","R01-AR-042460","M01-RR-00079","R01 AR060366","P01 AI083194","P20 RR020143","K24 AR002138","AR-42525","UL1 RR024148","P01 AR049084","HD-07463","AR-044804"],"pubmed_authors":["Grimaudo S","BIOLUPUS Network","Ojwang JO","Choi CB","Caprarulo C","Guilleron C","Reveille JD","Martins da Silva B","Roman JS","Tsao BP","Cecena MM","Rıos MC","Martin J","Battagliotti CG","Comeau ME","Junker P","Sung YK","Drenkard C","Calleja JL","Acevedo E","Pons-Estel BA","Merrill JT","Gutierrez C","Jorfen M","Truedsson L","Langefeld CD","Caeiro F","Alvarellos A","Sabio M","Kim K","Williams AH","Kim EM","Buchanan G","Bijl M","Berbotto GA","Anaya JM","Sebastiani GD","Gilkeson GS","Vyse TJ","Lauwerys BR","Brown EE","Manni J","Santos CD","Genoma en Lupus Network","Garcia MA","Kallenberg C","Paira S","Boackle SA","Marino PC","Navarro SM","Ortego N","Suarez A","Glenn SB","Allievi A","Eimon A","Motta EL","Cucho M","Catoggio LJ","Gallant CJ","Kaufman KM","Kang C","Ramos FA","Garcıa de la Torre I","Alarcon GS","Abdala M","D'Alfonso S","de Ramon Garrido E","Marcos JC","Scorza R","Criswell LA","James JA","Ramsey-Goldman R","Freedman BI","Galleazzi M","Adler A","Marcos AI","Palatnik SA","Bearzotti M","Laustrup H","Figueroa IR","Vila LM","Romero EJ","Scherbarth HR","Scofield RH","Perandones CE","Petri M","Bertoli A","Roverano S","Guthridge JM","Kimberly RP","Park SY","Niewold TB","Harley IT","Alarcon-Riquelme ME","Gaffney PM","Harley JB","Namjou B","Gamron S","Tate GA","Jacob CO","Endreffy E","Kovacs L","Prigione C","Presas JL","Soriano ER","Menso E","Moser KL","Bae SC","Stevens AM","Danieli MD","Moctezuma JF","Migliaresi S","Kelly JA","Bertero E","Graf CE","Vasconcelos C","Edberg J","Kamen DL"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of TRAF6 in a large multiancestral lupus cohort.","description":"<h4>Objective</h4>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development.<h4>Methods</h4>Fifteen single-nucleotide polymorphisms (SNPs) across TRAF6 were evaluated in 7,490 SLE patients and 6,780 control subjects from different ancestries. Population-based case-control association analyses and meta-analyses were performed. P values, false discovery rate q values, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.<h4>Results</h4>Evidence of associatio","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jun","modification":"2026-04-30T09:49:10.782Z","creation":"2026-04-07T15:58:09.406Z"},"accession":"S-EPMC3380425","cross_references":{"pubmed":["22231568"],"doi":["10.1002/art.34361"]}}