biostudies-literatureNamjou BBLRD VANICHD NIH HHSNCATS NIH HHSNCRR NIH HHSNIDDK NIH HHSNIAID NIH HHSNCI NIH HHSNIAMS NIH HHSNIGMS NIH HHS1960-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC3380425biostudies-literatureUnknown64(6)<h4>Objective</h4>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development.<h4>Methods</h4>Fifteen single-nucleotide polymorphisms (SNPs) across TRAF6 were evaluated in 7,490 SLE patients and 6,780 control subjects from different ancestries. Population-based case-control association analyses and meta-analyses were performed. P values, false discovery rate q values, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.<h4>Results</h4>Evidence of associatioArthritis and rheumatismEvaluation of TRAF6 in a large multiancestral lupus cohort.PMC3380425R01 AR044804P20 RR015577UL1 TR000154P30 RR031152P20-RR-015577UL1-RR-025741P60 AR062755R01 CA141700K24-AR-002138R01 AI063622I01 BX003850K24 AI078004P60-AR-049459UL1 RR024999P60 AR049459UL1 RR0250055UL1-RR-025777N01-AR-062277P30 AR053483M01 RR000079AR-058554P30 DK042086U19-AI-082714P60-AR-053308R01 AR052300UL1 RR029882R21 AI070304CA-141700-01P60 AR030692P50-AR-048940AI-063622P30-DK-42086UL1-RR-024999R01 AR043274R01 AR042460UL1 RR025777R21-AI-070304T32 GM063483P50 AR048940AR-043814P01-AR-049084L30 AI071651RR-031152T32 HD007463UL1-RR-029882AR-052300P20-RR-020143R01 AR042525R01 AR043814K08-AI-083790U19 AI082714AR-043274N01 AR062277GM-063483UL1-RR-025005R01-AR-33062AR-060366AI-071651AR-053483UL1 RR025741R37 AI024717P01-AI-083194P60-2-AR-030692P60 AR053308UL1 TR000062R01 AR033062RC1 AR058554R01 AR057172R01 AR043727AR-43727K08 AI083790R37-AI-024717R01-AR-042460M01-RR-00079R01 AR060366P01 AI083194P20 RR020143K24 AR002138AR-42525UL1 RR024148P01 AR049084HD-07463AR-044804Grimaudo SBIOLUPUS NetworkOjwang JOChoi CBCaprarulo CGuilleron CReveille JDMartins da Silva BRoman JSTsao BPCecena MMRıos MCMartin JBattagliotti CGComeau MEJunker PSung YKDrenkard CCalleja JLAcevedo EPons-Estel BAMerrill JTGutierrez CJorfen MTruedsson LLangefeld CDCaeiro FAlvarellos ASabio MKim KWilliams AHKim EMBuchanan GBijl MBerbotto GAAnaya JMSebastiani GDGilkeson GSVyse TJLauwerys BRBrown EEManni JSantos CDGenoma en Lupus NetworkGarcia MAKallenberg CPaira SBoackle SAMarino PCNavarro SMOrtego NSuarez AGlenn SBAllievi AEimon AMotta ELCucho MCatoggio LJGallant CJKaufman KMKang CRamos FAGarcıa de la Torre IAlarcon GSAbdala MD'Alfonso Sde Ramon Garrido EMarcos JCScorza RCriswell LAJames JARamsey-Goldman RFreedman BIGalleazzi MAdler AMarcos AIPalatnik SABearzotti MLaustrup HFigueroa IRVila LMRomero EJScherbarth HRScofield RHPerandones CEPetri MBertoli ARoverano SGuthridge JMKimberly RPPark SYNiewold TBHarley ITAlarcon-Riquelme MEGaffney PMHarley JBNamjou BGamron STate GAJacob COEndreffy EKovacs LPrigione CPresas JLSoriano ERMenso EMoser KLBae SCStevens AMDanieli MDMoctezuma JFMigliaresi SKelly JABertero EGraf CEVasconcelos CEdberg JKamen DLfalseEvaluation of TRAF6 in a large multiancestral lupus cohort.<h4>Objective</h4>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development.<h4>Methods</h4>Fifteen single-nucleotide polymorphisms (SNPs) across TRAF6 were evaluated in 7,490 SLE patients and 6,780 control subjects from different ancestries. Population-based case-control association analyses and meta-analyses were performed. P values, false discovery rate q values, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.<h4>Results</h4>Evidence of associatio2012-01-01T00:00:00Z2012 Jun2026-04-30T09:49:10.782Z2026-04-07T15:58:09.406ZS-EPMC33804252223156810.1002/art.34361