{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(5)"],"submitter":["Tseng CW"],"pubmed_abstract":["microRNAs (miRNAs) cause mRNA degradation or translation suppression of their target genes. Previous studies have found direct involvement of miRNAs in cancer initiation and progression. Artificial miRNAs, designed to target single or multiple genes of interest, provide a new therapeutic strategy for cancer. This study investigates the anti-tumor effect of a novel artificial miRNA, miR P-27-5p, on breast cancer. In this study, we reveal that miR P-27-5p downregulates the differential gene expressions associated with the protein modification process and regulation of cell cycle in T-47D cells. Introduction of this novel artificial miRNA, miR P-27-5p, into breast cell lines inhibits cell proliferation and induces the first \"gap\" phase (G1) cell cycle arrest in cancer cell lines but does not "],"journal":["International journal of molecular sciences"],"pagination":["6352-6369"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3382822"],"repository":["biostudies-literature"],"pubmed_title":["Revealing the anti-tumor effect of artificial miRNA p-27-5p on human breast carcinoma cell line T-47D."],"pmcid":["PMC3382822"],"pubmed_authors":["Chang JY","Chang YY","Hsu CC","Tseng CW","Shih AC","Li WH","Juan HF","Huang HC"],"additional_accession":[]},"is_claimable":false,"name":"Revealing the anti-tumor effect of artificial miRNA p-27-5p on human breast carcinoma cell line T-47D.","description":"microRNAs (miRNAs) cause mRNA degradation or translation suppression of their target genes. Previous studies have found direct involvement of miRNAs in cancer initiation and progression. Artificial miRNAs, designed to target single or multiple genes of interest, provide a new therapeutic strategy for cancer. This study investigates the anti-tumor effect of a novel artificial miRNA, miR P-27-5p, on breast cancer. In this study, we reveal that miR P-27-5p downregulates the differential gene expressions associated with the protein modification process and regulation of cell cycle in T-47D cells. Introduction of this novel artificial miRNA, miR P-27-5p, into breast cell lines inhibits cell proliferation and induces the first \"gap\" phase (G1) cell cycle arrest in cancer cell lines but does not ","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2026-04-07T15:17:06.266Z","creation":"2019-03-27T00:54:53Z"},"accession":"S-EPMC3382822","cross_references":{"pubmed":["22754369"],"doi":["10.3390/ijms13056352"]}}