{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(14)"],"submitter":["Jaschke A"],"pubmed_abstract":["The uptake and processing of dietary lipids by the small intestine is a multistep process that involves several steps including vesicular and protein transport. The GTPase ADP-ribosylation factor-related protein 1 (ARFRP1) controls the ARF-like 1 (ARL1)-mediated Golgi recruitment of GRIP domain proteins which in turn bind several Rab-GTPases. Here, we describe the essential role of ARFRP1 and its interaction with Rab2 in the assembly and lipidation of chylomicrons in the intestinal epithelium. Mice lacking Arfrp1 specifically in the intestine (Arfrp1(vil-/-)) exhibit an early post-natal growth retardation with reduced plasma triacylglycerol and free fatty acid concentrations. Arfrp1(vil-/-) enterocytes as well as Arfrp1 mRNA depleted Caco-2 cells absorbed fatty acids normally but secreted "],"journal":["Human molecular genetics"],"pagination":["3128-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3384381"],"repository":["biostudies-literature"],"pubmed_title":["The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium."],"pmcid":["PMC3384381"],"pubmed_authors":["Heeren J","Moser M","Brigelius-Flohe R","Petzke KJ","Hesse D","Puchkov D","Koepsell H","Joost HG","Zahn C","Chung B","Kluge R","Jaschke A","Schurmann A"],"additional_accession":[]},"is_claimable":false,"name":"The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.","description":"The uptake and processing of dietary lipids by the small intestine is a multistep process that involves several steps including vesicular and protein transport. The GTPase ADP-ribosylation factor-related protein 1 (ARFRP1) controls the ARF-like 1 (ARL1)-mediated Golgi recruitment of GRIP domain proteins which in turn bind several Rab-GTPases. Here, we describe the essential role of ARFRP1 and its interaction with Rab2 in the assembly and lipidation of chylomicrons in the intestinal epithelium. Mice lacking Arfrp1 specifically in the intestine (Arfrp1(vil-/-)) exhibit an early post-natal growth retardation with reduced plasma triacylglycerol and free fatty acid concentrations. Arfrp1(vil-/-) enterocytes as well as Arfrp1 mRNA depleted Caco-2 cells absorbed fatty acids normally but secreted ","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2025-04-05T13:05:24.093Z","creation":"2019-03-27T00:55:01Z"},"accession":"S-EPMC3384381","cross_references":{"pubmed":["22505585"],"doi":["10.1093/hmg/dds140"]}}