{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cifarelli V"],"funding":["NIDDK NIH HHS"],"pagination":["1213-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3385789"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(7)"],"pubmed_abstract":["Chronic hyperglycemia exerts a deleterious effect on endothelium, contributing to endothelial dysfunction and microvascular complications in poorly controlled diabetes. To understand the underlying mechanism, we studied the effect of endothelin-1 (ET-1) on endothelial production of Forkhead box O1 (FOXO1), a forkhead transcription factor that plays an important role in cell survival. ET-1 is a 21-amino acid peptide that is secreted primarily from endothelium. Using adenovirus-mediated gene transfer approach, we delivered FOXO1 cDNA into cultured human aorta endothelial cells. FOXO1 was shown to stimulate B cell leukemia/lymphoma 2-associated death promoter (BAD) production and promote cellular apoptosis. This effect was counteracted by ET-1. In response to ET-1, FOXO1 was phosphorylated an"],"journal":["Molecular endocrinology (Baltimore, Md.)"],"pubmed_title":["FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival."],"pmcid":["PMC3385789"],"funding_grant_id":["R01 DK087764","DK087764"],"pubmed_authors":["Kim DH","Lee S","Zhang T","Dong HH","Trucco M","Kamagate A","Bertera S","Cifarelli V","Slusher S","Luppi P"],"additional_accession":[]},"is_claimable":false,"name":"FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival.","description":"Chronic hyperglycemia exerts a deleterious effect on endothelium, contributing to endothelial dysfunction and microvascular complications in poorly controlled diabetes. To understand the underlying mechanism, we studied the effect of endothelin-1 (ET-1) on endothelial production of Forkhead box O1 (FOXO1), a forkhead transcription factor that plays an important role in cell survival. ET-1 is a 21-amino acid peptide that is secreted primarily from endothelium. Using adenovirus-mediated gene transfer approach, we delivered FOXO1 cDNA into cultured human aorta endothelial cells. FOXO1 was shown to stimulate B cell leukemia/lymphoma 2-associated death promoter (BAD) production and promote cellular apoptosis. This effect was counteracted by ET-1. In response to ET-1, FOXO1 was phosphorylated an","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2025-04-05T13:05:09.376Z","creation":"2019-03-27T00:55:02Z"},"accession":"S-EPMC3385789","cross_references":{"pubmed":["22570335"],"doi":["10.1210/me.2011-1276"]}}