{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weber KS"],"funding":["NIAID NIH HHS"],"pagination":["9511-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3386110"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(24)"],"pubmed_abstract":["Helper T cells are critical for protective immunity, CD8(+) T-cell memory, and CD4(+) recall responses, but whether the same or distinct CD4(+) T cells are involved in these responses has not been established. Here we describe two CD4(+) T cells, LLO118 and LLO56, specific for an immunodominant Listeria monocytogenes epitope, with dramatically different responses to primary and secondary infection. Comparing in vivo responses, LLO118 T cells proliferate more strongly to primary infection, whereas surprisingly, LLO56 has a superior CD4(+) recall response to secondary infection. LLO118 T cells provide more robust help for CD8(+) T-cell responses to secondary infection than LLO56. We found no detectable differences in antigen sensitivity, but naive LLO118 T cells have much lower levels of CD5 and their T-cell receptor levels are dramatically down-regulated after their strong primary response. Thus, distinct CD4(+) helper T cells are specialized to help either in primary or secondary responses to infection."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Distinct CD4+ helper T cells involved in primary and secondary responses to infection."],"pmcid":["PMC3386110"],"funding_grant_id":["P01 AI071195","U54 AI057160","R01 AI091878","T32 AI007290","R01 AI024157"],"pubmed_authors":["Li QJ","Campbell JD","Persaud SP","Davis MM","Allen PM","Weber KS"],"additional_accession":[]},"is_claimable":false,"name":"Distinct CD4+ helper T cells involved in primary and secondary responses to infection.","description":"Helper T cells are critical for protective immunity, CD8(+) T-cell memory, and CD4(+) recall responses, but whether the same or distinct CD4(+) T cells are involved in these responses has not been established. Here we describe two CD4(+) T cells, LLO118 and LLO56, specific for an immunodominant Listeria monocytogenes epitope, with dramatically different responses to primary and secondary infection. Comparing in vivo responses, LLO118 T cells proliferate more strongly to primary infection, whereas surprisingly, LLO56 has a superior CD4(+) recall response to secondary infection. LLO118 T cells provide more robust help for CD8(+) T-cell responses to secondary infection than LLO56. We found no detectable differences in antigen sensitivity, but naive LLO118 T cells have much lower levels of CD5 and their T-cell receptor levels are dramatically down-regulated after their strong primary response. Thus, distinct CD4(+) helper T cells are specialized to help either in primary or secondary responses to infection.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jun","modification":"2021-02-20T11:16:13Z","creation":"2019-03-27T00:55:03Z"},"accession":"S-EPMC3386110","cross_references":{"pubmed":["22645349"],"doi":["10.1073/pnas.1202408109"]}}