{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ruan Y"],"funding":["NIAAA NIH HHS"],"pagination":["2554-66"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3386807"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(7)"],"pubmed_abstract":["Coordinated translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribosome biogenesis and translation initiation often lead to tumor transformation and survival. Hepatocellular carcinoma (HCC) is among the most common and aggressive cancers worldwide and generally displays inherently high resistance to chemotherapeutic drugs. We found that RACK1, the receptor for activated C-kinase 1, was highly expressed in normal liver and frequently upregulated in HCC. Aberrant expression of RACK1 contributed to in vitro chemoresistance as well as in vivo tumor growth of HCC. These effects depended on ribosome localization of RACK1. Ribosomal RACK1 coupled with PKCβII to promote the phosphorylation of eukaryotic initiation factor 4E (eIF4E), which led to prefer"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma."],"pmcid":["PMC3386807"],"funding_grant_id":["R01 AA020203"],"pubmed_authors":["Zhou L","Ruan Y","Zhu H","Hao Y","Xu J","Wang L","Sun L","Zhang W","Guo L","Shen A","Yun X","Xie J","Gu J"],"additional_accession":[]},"is_claimable":false,"name":"Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma.","description":"Coordinated translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribosome biogenesis and translation initiation often lead to tumor transformation and survival. Hepatocellular carcinoma (HCC) is among the most common and aggressive cancers worldwide and generally displays inherently high resistance to chemotherapeutic drugs. We found that RACK1, the receptor for activated C-kinase 1, was highly expressed in normal liver and frequently upregulated in HCC. Aberrant expression of RACK1 contributed to in vitro chemoresistance as well as in vivo tumor growth of HCC. These effects depended on ribosome localization of RACK1. Ribosomal RACK1 coupled with PKCβII to promote the phosphorylation of eukaryotic initiation factor 4E (eIF4E), which led to prefer","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2026-05-04T19:13:15.962Z","creation":"2019-03-27T00:55:05Z"},"accession":"S-EPMC3386807","cross_references":{"pubmed":["22653060"],"doi":["10.1172/jci58488","10.1172/JCI58488"]}}