{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Randolph AG"],"funding":["NIAID NIH HHS","NHLBI NIH HHS"],"pagination":["e1450-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3387899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["128(6)"],"pubmed_abstract":["<h4>Background</h4>The 2009 pandemic influenza A (H1N1) (pH1N1) virus continues to circulate worldwide. Determining the roles of chronic conditions and bacterial coinfection in mortality is difficult because of the limited data for children with pH1N1-related critical illness.<h4>Methods</h4>We identified children (<21 years old) with confirmed or probable pH1N1 admitted to 35 US PICUs from April 15, 2009, through April 15, 2010. We collected data on demographics, baseline health, laboratory results, treatments, and outcomes.<h4>Results</h4>Of 838 children with pH1N1 admitted to a PICU, the median age was 6 years, 58% were male, 70% had ≥1 chronic health condition, and 88.2% received oseltamivir (5.8% started before PICU admission). Most patients had respiratory failure with 564 (67.3%) re"],"journal":["Pediatrics"],"pubmed_title":["Critically ill children during the 2009-2010 influenza pandemic in the United States."],"pmcid":["PMC3387899"],"funding_grant_id":["N01 HR056179","R56 AI084011","N01 HR 56179"],"pubmed_authors":["Levin DL","Tallie E","Martino K","Simon J","Rice TW","Mijares Y","Gurrola R","Smoot E","Doctor A","Anas N","Sanders RC","Mourani P","Turner DA","Agan A","Barker R","Tate S","Berry P","Cholette J","Clair A","Luther K","Greathouse K","Graciano AL","Spear D","Montgomery V","Markovitz B","Paden M","Osborne S","Burr S","Hefley G","Ayala A","Baldwin M","Toney R","Ackerman K","Richardson K","Kyle U","Vaughn F","McLaughlin G","Higgerson R","Murkowski K","Philip Barton R","Gedeit R","Dean Jarvis J","Loftis LL","Carroll CL","Czaja A","Wincek J","Hall MW","Jaimon N","Diliberto MA","Giuliano JS","Sullivan R","Yu R","Long J","Randolph AG","Truemper E","Randolph A","Rhodes T","Helfaer M","Thomas N","Dallis C","Terry J","Yoon G","Tellez DW","Raymond J","Rubinson L","Cheng R","Convery M","Murakami S","Traul C","Surender R","Babbitt C","Tanaka L","White B","Kay Henry Y","Thompson BT","Sapru A","Pediatric Acute Lung Injury and Sepsis Investigator's Network and the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network","Woodward V","Willson DF","Sadhu I","Darnell C","Bembea M","Zink M","Brown K","Ann Christie L","Flori H","Uyeki TM","Kirby A","Zimmerman J","Barr R","Waters K","Hicks B"],"additional_accession":[]},"is_claimable":false,"name":"Critically ill children during the 2009-2010 influenza pandemic in the United States.","description":"<h4>Background</h4>The 2009 pandemic influenza A (H1N1) (pH1N1) virus continues to circulate worldwide. Determining the roles of chronic conditions and bacterial coinfection in mortality is difficult because of the limited data for children with pH1N1-related critical illness.<h4>Methods</h4>We identified children (<21 years old) with confirmed or probable pH1N1 admitted to 35 US PICUs from April 15, 2009, through April 15, 2010. We collected data on demographics, baseline health, laboratory results, treatments, and outcomes.<h4>Results</h4>Of 838 children with pH1N1 admitted to a PICU, the median age was 6 years, 58% were male, 70% had ≥1 chronic health condition, and 88.2% received oseltamivir (5.8% started before PICU admission). Most patients had respiratory failure with 564 (67.3%) re","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2026-05-04T19:13:33.389Z","creation":"2019-03-27T00:55:08Z"},"accession":"S-EPMC3387899","cross_references":{"pubmed":["22065262"],"doi":["10.1542/peds.2011-0774"]}}