biostudies-literatureUnknown63(10)Routaboul JMLittle is known about the range and the genetic bases of naturally occurring variation for flavonoids. Using Arabidopsis thaliana seed as a model, the flavonoid content of 41 accessions and two recombinant inbred line (RIL) sets derived from divergent accessions (Cvi-0×Col-0 and Bay-0×Shahdara) were analysed. These accessions and RILs showed mainly quantitative rather than qualitative changes. To dissect the genetic architecture underlying these differences, a quantitative trait locus (QTL) analysis was performed on the two segregating populations. Twenty-two flavonoid QTLs were detected that accounted for 11-64% of the observed trait variations, only one QTL being common to both RIL sets. Sixteen of these QTLs were confirmed and coarsely mapped using heterogeneous inbred families (HIFs). Journal of experimental botany3749-64https://www.ebi.ac.uk/biostudies/studies/S-EPMC3388840biostudies-literatureMetabolite profiling and quantitative genetics of natural variation for flavonoids in Arabidopsis.PMC3388840Loudet OBidzinski PMarquis CLepiniec LRoutaboul JMDubos CBeck GfalseMetabolite profiling and quantitative genetics of natural variation for flavonoids in Arabidopsis.Little is known about the range and the genetic bases of naturally occurring variation for flavonoids. Using Arabidopsis thaliana seed as a model, the flavonoid content of 41 accessions and two recombinant inbred line (RIL) sets derived from divergent accessions (Cvi-0×Col-0 and Bay-0×Shahdara) were analysed. These accessions and RILs showed mainly quantitative rather than qualitative changes. To dissect the genetic architecture underlying these differences, a quantitative trait locus (QTL) analysis was performed on the two segregating populations. Twenty-two flavonoid QTLs were detected that accounted for 11-64% of the observed trait variations, only one QTL being common to both RIL sets. Sixteen of these QTLs were confirmed and coarsely mapped using heterogeneous inbred families (HIFs). 2012-01-01T00:00:00Z2012 Jun2026-05-04T19:13:35.901Z2026-04-24T03:09:02.309ZS-EPMC33888402244242610.1093/jxb/ers067