{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Ma Z"],"pubmed_abstract":["Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation."],"journal":["Beilstein journal of organic chemistry"],"pagination":["829-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3388871"],"repository":["biostudies-literature"],"pubmed_title":["An intramolecular inverse electron demand Diels-Alder approach to annulated α-carbolines."],"pmcid":["PMC3388871"],"pubmed_authors":["Schaus SE","Ni F","Snyder JK","Lo SM","Ma Z","Roveto PM","Woo GH"],"additional_accession":[]},"is_claimable":false,"name":"An intramolecular inverse electron demand Diels-Alder approach to annulated α-carbolines.","description":"Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012","modification":"2025-04-05T13:20:22.676Z","creation":"2019-03-27T00:55:11Z"},"accession":"S-EPMC3388871","cross_references":{"pubmed":["23015831"],"doi":["10.3762/bjoc.8.93"]}}