biostudies-literatureUnknown8Ma ZIntramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation.Beilstein journal of organic chemistry829-40https://www.ebi.ac.uk/biostudies/studies/S-EPMC3388871biostudies-literatureAn intramolecular inverse electron demand Diels-Alder approach to annulated α-carbolines.PMC3388871Schaus SENi FSnyder JKLo SMMa ZRoveto PMWoo GHfalseAn intramolecular inverse electron demand Diels-Alder approach to annulated α-carbolines.Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation.2012-01-01T00:00:00Z20122025-04-05T13:20:22.676Z2019-03-27T00:55:11ZS-EPMC33888712301583110.3762/bjoc.8.93