{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gildner PG"],"funding":["NCRR NIH HHS"],"pagination":["9942-5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3389751"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134(24)"],"pubmed_abstract":["The C-alkylation of nitroalkanes under mild conditions has been a significant challenge in organic synthesis for more than a century. Herein we report a simple Cu(I) catalyst, generated in situ, that is highly effective for C-benzylation of nitroalkanes using abundant benzyl bromides and related heteroaromatic compounds. This process, which we believe proceeds via a thermal redox mechanism, allows access to a variety of complex nitroalkanes under mild reaction conditions and represents the first step toward the development of a general catalytic system for the alkylation of nitroalkanes."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Benzylation of nitroalkanes using copper-catalyzed thermal redox catalysis: toward the facile C-alkylation of nitroalkanes."],"pmcid":["PMC3389751"],"funding_grant_id":["S10 RR02692","S10 RR026962","P20 RR017716"],"pubmed_authors":["Gildner PG","Watson DA","Cui D","Gietter AA"],"additional_accession":[]},"is_claimable":false,"name":"Benzylation of nitroalkanes using copper-catalyzed thermal redox catalysis: toward the facile C-alkylation of nitroalkanes.","description":"The C-alkylation of nitroalkanes under mild conditions has been a significant challenge in organic synthesis for more than a century. Herein we report a simple Cu(I) catalyst, generated in situ, that is highly effective for C-benzylation of nitroalkanes using abundant benzyl bromides and related heteroaromatic compounds. This process, which we believe proceeds via a thermal redox mechanism, allows access to a variety of complex nitroalkanes under mild reaction conditions and represents the first step toward the development of a general catalytic system for the alkylation of nitroalkanes.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jun","modification":"2024-12-04T12:54:25.673Z","creation":"2019-03-26T23:29:58Z"},"accession":"S-EPMC3389751","cross_references":{"pubmed":["22691127"],"doi":["10.1021/ja304561c"]}}