{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chaplin JW"],"funding":["NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["4199-209"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3394853"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["187(8)"],"pubmed_abstract":["CD180 is homologous to TLR4 and regulates TLR4 signaling, yet its function is unclear. We report that injection of anti-CD180 mAb into mice induced rapid Ig production of all classes and subclasses, with the exception of IgA and IgG2b, with up to 50-fold increases in serum IgG1 and IgG3. IgG production after anti-CD180 injection was not due to reactivation of memory B cells and was retained in T cell-deficient (TCR knockout [KO]), CD40 KO, IL-4 KO, and MyD88 KO mice. Anti-CD180 rapidly increased both transitional and mature B cells, with especially robust increases in transitional B cell number, marginal zone B cell proliferation, and CD86, but not CD80, expression. In contrast, anti-CD40 induced primarily follicular B cell and myeloid expansion, with increases in expression of CD80 and CD"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway."],"pmcid":["PMC3394853"],"funding_grant_id":["R21 AI085311","AI44257","2T32 GM007270","AI52203","R37 AI044257","AI85311","R01 AI052203","T32 GM007270","R01 AI044257"],"pubmed_authors":["Ledbetter JA","Kasahara S","Clark EA","Chaplin JW"],"additional_accession":[]},"is_claimable":false,"name":"Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway.","description":"CD180 is homologous to TLR4 and regulates TLR4 signaling, yet its function is unclear. We report that injection of anti-CD180 mAb into mice induced rapid Ig production of all classes and subclasses, with the exception of IgA and IgG2b, with up to 50-fold increases in serum IgG1 and IgG3. IgG production after anti-CD180 injection was not due to reactivation of memory B cells and was retained in T cell-deficient (TCR knockout [KO]), CD40 KO, IL-4 KO, and MyD88 KO mice. Anti-CD180 rapidly increased both transitional and mature B cells, with especially robust increases in transitional B cell number, marginal zone B cell proliferation, and CD86, but not CD80, expression. In contrast, anti-CD40 induced primarily follicular B cell and myeloid expansion, with increases in expression of CD80 and CD","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Oct","modification":"2025-04-18T16:16:09.606Z","creation":"2019-03-27T00:55:30Z"},"accession":"S-EPMC3394853","cross_references":{"pubmed":["21918197"],"doi":["10.4049/jimmunol.1100198"]}}