{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meguro A"],"funding":["Intramural NIH HHS"],"pagination":["1557-65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3401481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(12)"],"pubmed_abstract":["Previously, we have shown that IL-21R(-/-) splenocytes ameliorate GVHD as compared with wild-type splenocytes. Here, we investigated whether or not IL-21R(-/-) splenocytes diminish the graft-versus-leukemia (GVL) effect. Surprisingly, IL-21R(-/-) splenocytes efficiently eliminate leukemic cells as well as wild-type splenocytes, suggesting the retention of GVL effects in the absence of IL-21 signaling. To compare the GVL effect between IL-21R(-/-) and wild-type cells, we titrated the number of splenocytes required for the elimination of leukemic cells and found that the threshold of GVL effect was obtained between 5 × 10(5) and 5 × 10(6) with both types of splenocytes. Cotransplantation with CD8-depleted splenocytes but not with purified CD8 T-cells resulted in a significant reduction in an"],"journal":["Bone marrow transplantation"],"pubmed_title":["Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells."],"pmcid":["PMC3401481"],"funding_grant_id":["ZIA HL005408-03"],"pubmed_authors":["Hatanaka K","Ozawa K","Tatara R","Oh I","Sakata Y","Leonard WJ","Ohmori T","Nakae S","Matsu H","Sudo K","Ozaki K","Sato K","Meguro A"],"additional_accession":[]},"is_claimable":false,"name":"Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells.","description":"Previously, we have shown that IL-21R(-/-) splenocytes ameliorate GVHD as compared with wild-type splenocytes. Here, we investigated whether or not IL-21R(-/-) splenocytes diminish the graft-versus-leukemia (GVL) effect. Surprisingly, IL-21R(-/-) splenocytes efficiently eliminate leukemic cells as well as wild-type splenocytes, suggesting the retention of GVL effects in the absence of IL-21 signaling. To compare the GVL effect between IL-21R(-/-) and wild-type cells, we titrated the number of splenocytes required for the elimination of leukemic cells and found that the threshold of GVL effect was obtained between 5 × 10(5) and 5 × 10(6) with both types of splenocytes. Cotransplantation with CD8-depleted splenocytes but not with purified CD8 T-cells resulted in a significant reduction in an","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Dec","modification":"2025-04-04T21:17:33.083Z","creation":"2019-03-27T00:55:49Z"},"accession":"S-EPMC3401481","cross_references":{"pubmed":["21258423"],"doi":["10.1038/bmt.2010.342"]}}