{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi J"],"funding":["British Heart Foundation"],"pagination":["2161-75"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3402779"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["166(7)"],"pubmed_abstract":["<h4>Background and purpose</h4>Endothelin(A) (ET(A) ) receptor-operated canonical transient receptor potential (TRPC) channels mediate Ca²⁺ influx pathways, which are important in coronary artery function. Biochemical pathways linking ET(A) receptor stimulation to TRPC channel opening are unknown. We investigated the involvement of phosphatidylinositol 3-kinases (PI3K) in ET(A) receptor activation of native heteromeric TRPC1/C5/C6 and TRPC3/C7 channels in rabbit coronary artery vascular smooth muscle cells (VSMCs).<h4>Experimental approach</h4>A pharmacological profile of PI3K was created by studying the effect of pan-PI3K, pan-Class I PI3K and Class I PI3K isoform-selective inhibitors on ET(A) receptor-evoked single TRPC1/C5/C6 and TRPC3/C7 channel activities in cell-attached patches from"],"journal":["British journal of pharmacology"],"pubmed_title":["Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A)  receptor-operated native TRPC channels in rabbit coronary artery myocytes."],"pmcid":["PMC3402779"],"funding_grant_id":["PG/08/042/25066","PG/07/079/23568"],"pubmed_authors":["Large WA","Albert AP","Ju M","Shi J"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A)  receptor-operated native TRPC channels in rabbit coronary artery myocytes.","description":"<h4>Background and purpose</h4>Endothelin(A) (ET(A) ) receptor-operated canonical transient receptor potential (TRPC) channels mediate Ca²⁺ influx pathways, which are important in coronary artery function. Biochemical pathways linking ET(A) receptor stimulation to TRPC channel opening are unknown. We investigated the involvement of phosphatidylinositol 3-kinases (PI3K) in ET(A) receptor activation of native heteromeric TRPC1/C5/C6 and TRPC3/C7 channels in rabbit coronary artery vascular smooth muscle cells (VSMCs).<h4>Experimental approach</h4>A pharmacological profile of PI3K was created by studying the effect of pan-PI3K, pan-Class I PI3K and Class I PI3K isoform-selective inhibitors on ET(A) receptor-evoked single TRPC1/C5/C6 and TRPC3/C7 channel activities in cell-attached patches from","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Aug","modification":"2025-04-05T13:00:24.082Z","creation":"2019-03-27T00:55:52Z"},"accession":"S-EPMC3402779","cross_references":{"pubmed":["22404177"],"doi":["10.1111/j.1476-5381.2012.01937.x"]}}