biostudies-literature00460Drummond MCIntramural NIH HHSNIDCD NIH HHS89-99https://www.ebi.ac.uk/biostudies/studies/S-EPMC3403717biostudies-literatureUnknown288(1-2)Hereditary deafness is genetically heterogeneous such that mutations of many different genes can cause hearing loss. This review focuses on the evidence and implications that several of these deafness genes encode actin-interacting proteins or actin itself. There is a growing appreciation of the contribution of the actin interactome in stereocilia development, maintenance, mechanotransduction and malfunction of the auditory system.Hearing researchActin in hair cells and hearing loss.PMC3403717DC004568R01 DC004568ZIA DC000048-13T32 DC000039Z01 DC000039DC000039-15Friderici KHBelyantseva IAFriedman TBDrummond MC46falseActin in hair cells and hearing loss.Hereditary deafness is genetically heterogeneous such that mutations of many different genes can cause hearing loss. This review focuses on the evidence and implications that several of these deafness genes encode actin-interacting proteins or actin itself. There is a growing appreciation of the contribution of the actin interactome in stereocilia development, maintenance, mechanotransduction and malfunction of the auditory system.2012-01-01T00:00:00Z2012 Jun2024-11-21T06:12:12.651Z2019-03-27T00:55:55ZS-EPMC34037172220060710.1016/j.heares.2011.12.003