{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pallan PS"],"funding":["NIGMS NIH HHS"],"pagination":["8195-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3404228"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(66)"],"pubmed_abstract":["Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications."],"journal":["Chemical communications (Cambridge, England)"],"pubmed_title":["Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs."],"pmcid":["PMC3404228"],"funding_grant_id":["R01 GM55237","R01 GM055237"],"pubmed_authors":["Egli M","Swayze EE","Prakash TP","Seth PP","Allerson CR","Pallan PS","Berdeja A"],"additional_accession":[]},"is_claimable":false,"name":"Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.","description":"Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Aug","modification":"2026-04-29T16:20:49.884Z","creation":"2019-03-27T00:55:56Z"},"accession":"S-EPMC3404228","cross_references":{"pubmed":["22614180"],"doi":["10.1039/c2cc32286b"]}}