{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(4)"],"submitter":["Schuster C"],"pubmed_abstract":["<h4>Background</h4>Aged patients (>50 years old) with residual schizophrenic symptoms differ from young patients. They represent a subpopulation with a more unfavorable Kraepelinian course and have an increased risk (up to 30%) for dementia of unknown origin. However, our current understanding of age-related brain changes in schizophrenia is derived from studies that included less than 17% of patients who were older than 50 years of age. This study investigated the anatomical distribution of gray matter (GM) brain deficits in aged patients with ongoing schizophrenia.<h4>Methods</h4>Voxel-based morphometry was applied to 3D-T1 magnetic resonance images obtained from 27 aged patients with schizophrenia (mean age of 60 years) and 40 age-matched normal controls.<h4>Results</h4>Older patients w"],"journal":["Schizophrenia bulletin"],"pagination":["796-802"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3406517"],"repository":["biostudies-literature"],"pubmed_title":["Gray matter volume decreases in elderly patients with schizophrenia: a voxel-based morphometry study."],"pmcid":["PMC3406517"],"pubmed_authors":["Schuller AM","Danion JM","Foucher JR","Schuster C","Paulos C","Namer I","Pull C"],"additional_accession":[]},"is_claimable":false,"name":"Gray matter volume decreases in elderly patients with schizophrenia: a voxel-based morphometry study.","description":"<h4>Background</h4>Aged patients (>50 years old) with residual schizophrenic symptoms differ from young patients. They represent a subpopulation with a more unfavorable Kraepelinian course and have an increased risk (up to 30%) for dementia of unknown origin. However, our current understanding of age-related brain changes in schizophrenia is derived from studies that included less than 17% of patients who were older than 50 years of age. This study investigated the anatomical distribution of gray matter (GM) brain deficits in aged patients with ongoing schizophrenia.<h4>Methods</h4>Voxel-based morphometry was applied to 3D-T1 magnetic resonance images obtained from 27 aged patients with schizophrenia (mean age of 60 years) and 40 age-matched normal controls.<h4>Results</h4>Older patients w","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jun","modification":"2025-07-03T03:04:42.76Z","creation":"2025-07-03T03:04:42.76Z"},"accession":"S-EPMC3406517","cross_references":{"pubmed":["21205677"],"doi":["10.1093/schbul/sbq150"]}}