biostudies-literatureUnknown38(4)Schuster C<h4>Background</h4>Aged patients (>50 years old) with residual schizophrenic symptoms differ from young patients. They represent a subpopulation with a more unfavorable Kraepelinian course and have an increased risk (up to 30%) for dementia of unknown origin. However, our current understanding of age-related brain changes in schizophrenia is derived from studies that included less than 17% of patients who were older than 50 years of age. This study investigated the anatomical distribution of gray matter (GM) brain deficits in aged patients with ongoing schizophrenia.<h4>Methods</h4>Voxel-based morphometry was applied to 3D-T1 magnetic resonance images obtained from 27 aged patients with schizophrenia (mean age of 60 years) and 40 age-matched normal controls.<h4>Results</h4>Older patients wSchizophrenia bulletin796-802https://www.ebi.ac.uk/biostudies/studies/S-EPMC3406517biostudies-literatureGray matter volume decreases in elderly patients with schizophrenia: a voxel-based morphometry study.PMC3406517Schuller AMDanion JMFoucher JRSchuster CPaulos CNamer IPull CfalseGray matter volume decreases in elderly patients with schizophrenia: a voxel-based morphometry study.<h4>Background</h4>Aged patients (>50 years old) with residual schizophrenic symptoms differ from young patients. They represent a subpopulation with a more unfavorable Kraepelinian course and have an increased risk (up to 30%) for dementia of unknown origin. However, our current understanding of age-related brain changes in schizophrenia is derived from studies that included less than 17% of patients who were older than 50 years of age. This study investigated the anatomical distribution of gray matter (GM) brain deficits in aged patients with ongoing schizophrenia.<h4>Methods</h4>Voxel-based morphometry was applied to 3D-T1 magnetic resonance images obtained from 27 aged patients with schizophrenia (mean age of 60 years) and 40 age-matched normal controls.<h4>Results</h4>Older patients w2012-01-01T00:00:00Z2012 Jun2025-07-03T03:04:42.76Z2025-07-03T03:04:42.76ZS-EPMC34065172120567710.1093/schbul/sbq150