{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lai LA"],"funding":["NIA NIH HHS","NCI NIH HHS"],"pagination":["180-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3406733"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["320(2)"],"pubmed_abstract":["BAC arrays were used to evaluate genomic instability along the colon of patients with ulcerative colitis (UC). Genomic instability increases with disease progression and biopsies more proximal to dysplasia showed increased instability. Pan-colonic field copy number gain or loss involving small (<1Mb) regions were detected in most patients and were particularly apparent in the UC progressor patients who had dysplasia or cancer. Chromosomal copy gains or losses affecting large regions were mainly restricted to dysplastic biopsies. Areas of significant chromosomal losses were detected in the UC progressors on chromosomes 2q36, 3q25, 3p21, 4q34, 4p16.2, 15q22, and 16p13 (p-value⩽0.04). These results extend our understanding of the dynamic nature of pan-colonic genomic instability in this disease."],"journal":["Cancer letters"],"pubmed_title":["Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer."],"pmcid":["PMC3406733"],"funding_grant_id":["K07 CA137136","P30 AG013280-05","P30 AG013280","P20 CA103728-05","P30 CA015704","P20 CA103728","R01 CA068124-11A1","R01 CA068124","P01 AG001751"],"pubmed_authors":["Rabinovitch PS","Lai LA","Bronner MP","Crispin D","Risques RA","Brentnall TA","Chen R"],"additional_accession":[]},"is_claimable":false,"name":"Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer.","description":"BAC arrays were used to evaluate genomic instability along the colon of patients with ulcerative colitis (UC). Genomic instability increases with disease progression and biopsies more proximal to dysplasia showed increased instability. Pan-colonic field copy number gain or loss involving small (<1Mb) regions were detected in most patients and were particularly apparent in the UC progressor patients who had dysplasia or cancer. Chromosomal copy gains or losses affecting large regions were mainly restricted to dysplastic biopsies. Areas of significant chromosomal losses were detected in the UC progressors on chromosomes 2q36, 3q25, 3p21, 4q34, 4p16.2, 15q22, and 16p13 (p-value⩽0.04). These results extend our understanding of the dynamic nature of pan-colonic genomic instability in this disease.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2025-04-04T00:48:43.027Z","creation":"2019-03-27T00:56:02Z"},"accession":"S-EPMC3406733","cross_references":{"pubmed":["22387989"],"doi":["10.1016/j.canlet.2012.02.031"]}}