{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["109(29)"],"submitter":["Donohoe TJ"],"pubmed_abstract":["The utilization of sequential palladium-catalyzed α-arylation and cyclization reactions provides a general approach to an array of isoquinolines and their corresponding N-oxides. This methodology allows the convergent combination of readily available precursors in a regioselective manner and in excellent overall yields. This powerful route to polysubstituted isoquinolines, which is not limited to electron rich moieties, also allows rapid access to analogues of biologically active compounds."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["11605-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3406859"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones."],"pmcid":["PMC3406859"],"pubmed_authors":["Donohoe TJ","Jones GR","Pilgrim BS","Bassuto JA"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.","description":"The utilization of sequential palladium-catalyzed α-arylation and cyclization reactions provides a general approach to an array of isoquinolines and their corresponding N-oxides. This methodology allows the convergent combination of readily available precursors in a regioselective manner and in excellent overall yields. This powerful route to polysubstituted isoquinolines, which is not limited to electron rich moieties, also allows rapid access to analogues of biologically active compounds.","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Jul","modification":"2025-04-19T02:53:38.625Z","creation":"2019-03-27T00:56:03Z"},"accession":"S-EPMC3406859","cross_references":{"pubmed":["22753504"],"doi":["10.1073/pnas.1206532109"]}}