biostudies-literatureLeibson CLNICHD NIH HHSNIA NIH HHS2038-49https://www.ebi.ac.uk/biostudies/studies/S-EPMC3408240biostudies-literatureUnknown29(11)Data on traumatic brain injury (TBI) economic outcomes are limited. We used Rochester Epidemiology Project (REP) resources to estimate long-term medical costs for clinically-confirmed incident TBI across the full range of severity after controlling for pre-existing conditions and co-occurring injuries. All Olmsted County, Minnesota, residents with diagnoses indicative of potential TBI from 1985-2000 (n=46,114) were identified, and a random sample (n=7175) was selected for medical record review to confirm case status, and to characterize as definite (moderate/severe), probable (mild), or possible (symptomatic) TBI. For each case, we identified one age- and sex-matched non-TBI control registered in REP in the same year (±1 year) as case's TBI. Cases with co-occurring non-head injuries were aJournal of neurotraumaMedical care costs associated with traumatic brain injury over the full spectrum of disease: a controlled population-based study.PMC3408240R01 AG034676HD07447Hall Long KMandrekar JMalec JFOsler TMBrown AWLeibson CLRansom JEfalseMedical care costs associated with traumatic brain injury over the full spectrum of disease: a controlled population-based study.Data on traumatic brain injury (TBI) economic outcomes are limited. We used Rochester Epidemiology Project (REP) resources to estimate long-term medical costs for clinically-confirmed incident TBI across the full range of severity after controlling for pre-existing conditions and co-occurring injuries. All Olmsted County, Minnesota, residents with diagnoses indicative of potential TBI from 1985-2000 (n=46,114) were identified, and a random sample (n=7175) was selected for medical record review to confirm case status, and to characterize as definite (moderate/severe), probable (mild), or possible (symptomatic) TBI. For each case, we identified one age- and sex-matched non-TBI control registered in REP in the same year (±1 year) as case's TBI. Cases with co-occurring non-head injuries were a2012-01-01T00:00:00Z2012 Jul2025-05-29T19:59:43.942Z2025-05-29T19:59:43.942ZS-EPMC34082402241402310.1089/neu.2010.1713