biostudies-literatureUnknown10Wilke S<h4>Background</h4>The family of lysosome-associated membrane proteins (LAMP) comprises the multifunctional, ubiquitous LAMP-1 and LAMP-2, and the cell type-specific proteins DC-LAMP (LAMP-3), BAD-LAMP (UNC-46, C20orf103) and macrosialin (CD68). LAMPs have been implicated in a multitude of cellular processes, including phagocytosis, autophagy, lipid transport and aging. LAMP-2 isoform A acts as a receptor in chaperone-mediated autophagy. LAMP-2 deficiency causes the fatal Danon disease. The abundant proteins LAMP-1 and LAMP-2 are major constituents of the glycoconjugate coat present on the inside of the lysosomal membrane, the 'lysosomal glycocalyx'. The LAMP family is characterized by a conserved domain of 150 to 200 amino acids with two disulfide bonds.<h4>Results</h4>The crystal structuBMC biology62https://www.ebi.ac.uk/biostudies/studies/S-EPMC3409847biostudies-literatureCrystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx.PMC3409847Wilke SBussow KKrausze JfalseCrystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx.<h4>Background</h4>The family of lysosome-associated membrane proteins (LAMP) comprises the multifunctional, ubiquitous LAMP-1 and LAMP-2, and the cell type-specific proteins DC-LAMP (LAMP-3), BAD-LAMP (UNC-46, C20orf103) and macrosialin (CD68). LAMPs have been implicated in a multitude of cellular processes, including phagocytosis, autophagy, lipid transport and aging. LAMP-2 isoform A acts as a receptor in chaperone-mediated autophagy. LAMP-2 deficiency causes the fatal Danon disease. The abundant proteins LAMP-1 and LAMP-2 are major constituents of the glycoconjugate coat present on the inside of the lysosomal membrane, the 'lysosomal glycocalyx'. The LAMP family is characterized by a conserved domain of 150 to 200 amino acids with two disulfide bonds.<h4>Results</h4>The crystal structu2012-01-01T00:00:00Z2012 Jul2025-05-29T19:44:11.217Z2025-05-29T19:44:11.217ZS-EPMC34098472280932610.1186/1741-7007-10-62