{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Oseroff C"],"funding":["NIAID NIH HHS"],"pagination":["1800-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3411923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["189(4)"],"pubmed_abstract":["A panel of 133 allergens derived from 28 different sources, including fungi, trees, grasses, weeds, and indoor allergens, was surveyed utilizing prediction of HLA class II-binding peptides and ELISPOT assays with PBMC from allergic donors, resulting in the identification of 257 T cell epitopes. More than 90% of the epitopes were novel, and for 14 allergen sources were the first ever identified to our knowledge. The epitopes identified in the different allergen sources summed up to a variable fraction of the total extract response. In cases of allergens in which the identified T cell epitopes accounted for a minor fraction of the extract response, fewer known protein sequences were available, suggesting that for low epitope coverage allergen sources, additional allergen proteins remain to b"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts."],"pmcid":["PMC3411923"],"funding_grant_id":["U19AI100275","N01 AI040023","R37 AI038425","R01 AI091614","U19 AI100275"],"pubmed_authors":["McKinney DM","Brodie TM","Sallusto F","Alam R","Peters B","Sette A","Sidney J","Vita R","Oseroff C","Kolla R","Southwood S","Grey H","Broide D","Tripple V","Greenbaum JA"],"additional_accession":[]},"is_claimable":false,"name":"T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts.","description":"A panel of 133 allergens derived from 28 different sources, including fungi, trees, grasses, weeds, and indoor allergens, was surveyed utilizing prediction of HLA class II-binding peptides and ELISPOT assays with PBMC from allergic donors, resulting in the identification of 257 T cell epitopes. More than 90% of the epitopes were novel, and for 14 allergen sources were the first ever identified to our knowledge. The epitopes identified in the different allergen sources summed up to a variable fraction of the total extract response. In cases of allergens in which the identified T cell epitopes accounted for a minor fraction of the extract response, fewer known protein sequences were available, suggesting that for low epitope coverage allergen sources, additional allergen proteins remain to b","dates":{"release":"2012-01-01T00:00:00Z","publication":"2012 Aug","modification":"2025-04-22T07:45:38.587Z","creation":"2019-03-26T23:42:57Z"},"accession":"S-EPMC3411923","cross_references":{"pubmed":["22786768"],"doi":["10.4049/jimmunol.1200850"]}}