biostudies-literatureJacques BEIntramural NIH HHSNCI NIH HHS27-39https://www.ebi.ac.uk/biostudies/studies/S-EPMC3412397biostudies-literatureUnknown289(1-2)The avian basilar papilla (BP) is a likely homolog of the auditory sensory epithelium of the mammalian cochlea, the organ of Corti. During mammalian development Fibroblast growth factor receptor-3 (Fgfr3) is known to regulate the differentiation of auditory mechanosensory hair cells (HCs) and supporting cells (SCs), both of which are required for sound detection. Fgfr3 is expressed in developing progenitor cells (PCs) and SCs of both the BP and the organ of Corti; however its role in BP development is unknown. Here we utilized an in vitro whole organ embryonic culture system to examine the role of Fgf signaling in the developing avian cochlea. SU5402 (an antagonist of Fgf signaling) was applied to developing BP cultures at different stages to assay the role of Fgf signaling during HC formaHearing researchFgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papilla.PMC3412397ZIA DC000059-11P30CA23100P30 CA023100Dabdoub AKelley MWJacques BEfalseFgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papilla.The avian basilar papilla (BP) is a likely homolog of the auditory sensory epithelium of the mammalian cochlea, the organ of Corti. During mammalian development Fibroblast growth factor receptor-3 (Fgfr3) is known to regulate the differentiation of auditory mechanosensory hair cells (HCs) and supporting cells (SCs), both of which are required for sound detection. Fgfr3 is expressed in developing progenitor cells (PCs) and SCs of both the BP and the organ of Corti; however its role in BP development is unknown. Here we utilized an in vitro whole organ embryonic culture system to examine the role of Fgf signaling in the developing avian cochlea. SU5402 (an antagonist of Fgf signaling) was applied to developing BP cultures at different stages to assay the role of Fgf signaling during HC forma2012-01-01T00:00:00Z2012 Jul2025-05-29T22:27:13.4Z2025-05-29T22:27:13.4ZS-EPMC34123972257579010.1016/j.heares.2012.04.018